Dr Caroline Abbott

My profile

Biography

Academic and professional qualifications

PhD

Expert reviewer for external funding bodies

I am an expert reviewer for journals Diabetes Care, Diabetologia, PLOS One, Medicina

Prizes and awards

Highly Commended’ in the Quality in Care Diabetes awards category: Seven Thousand Feet. ‘Diabetes Collaboration Initiative of the year – Adults’. 2019.

Best Public Engagement Contribution Award at The Greater Manchester Clinical Research Network part of the National Institute for Health Research: ‘Seven Thousand Feet’ (Art-Science event on diabetes), October 2019.

Outstanding Contribution to Patient and Public Involvement and Engagement 2019: ‘Seven Thousand Feet’. University of Manchester PPIE event: July 2019.

Prize Lecture - The Paul Wilson Brand Repetitive Stress Award (2018), Diabetic Foot Study Group meeting, Berlin, Germany.

Young Investigator Clinical Science Award for 2007, NEURODIAB European Association for the Study of Diabetes (EASD) meeting, Utrecht, Netherlands.

Editorial Board membership

Editorial Board member for Medicina (international, open access journal) - since March 2021.

Personal website address

https://www.researchgate.net/profile/Caroline-Abbott-4

Teaching

Supervision

PhD supervision to completion and in progress

Research outputs

I am a Research Fellow in Department of Life Sciences, Faculty of Science and Engineering at Manchester Metropolitan University.
I have been active in clinical research of diabetic lower limb disease for over 25 years, in particular: epidemiology and aetiology of diabetic foot ulcers, diabetic neuropathy, peripheral vascular disease and lower limb amputation. I have a special interest in the ethnic variations associated with risk of diabetic lower limb disease. My research in clinical movement disorders includes: diabetic plantar forces during gait, comparative plantar pressure measuring devices, and use of smart technologies for diabetic foot ulcer prevention. My publications have had over 7,000 citations and a H-index of 27 (Google scholar).
I am currently leading a pilot clinical trial of a new medical device for remote diabetic foot ulcer prevention (joint Chief Investigator, and Principal Investigator).

  • Chapters in books

    Reeves, N.D., Cassidy, B., Abbott, C.A., Yap, M.H. (2021) 'Novel technologies for detection and prevention of diabetic foot ulcers.' The Science, Etiology and Mechanobiology of Diabetes and its Complications. pp. 107-122.

    Abbott, C.A. (2019) 'Epidemiology of amputation and the influence of ethnicity.' The Foot in Diabetes, 5th Edition. John Wiley and Sons Ltd,

  • Journal articles

    Abbott, C.A., Chatwin, K.E., Rajbhandari, S.M., John, K.M., Pabbineedi, S., Bowling, F.L., Boulton, A.J.M., Reeves, N.D. (2022) 'Site-Specific, Critical Threshold Barefoot Peak Plantar Pressure Associated with Diabetic Foot Ulcer History: A Novel Approach to Determine DFU Risk in the Clinical Setting.' Medicina, 58(2)

    Chatwin, K.E., Abbott, C.A., Rajbhandari, S.M., Reddy, P.N., Bowling, F.L., Boulton, A.J.M., Reeves, N.D. (2021) 'An intelligent insole system with personalised digital feedback reduces foot pressures during daily life: An 18-month randomised controlled trial.' Diabetes Research and Clinical Practice, 181pp. 109091-109091.

    Chappell, F.M., Crawford, F., Horne, M., Leese, G.P., Martin, A., Weller, D., Boulton, A.J.M., Abbott, C., Monteiro-Soares, M., Veves, A., Riley, R.D. (2021) 'Development and validation of a clinical prediction rule for development of diabetic foot ulceration: an analysis of data from five cohort studies..' BMJ Open Diabetes Research and Care, 9

    Ferdousi, M., Kalteniece, A., Azmi, S., Petropoulos, I.N., Ponirakis, G., Alam, U., Asghar, O., Marshall, A., Fullwood, C., Jeziorska, M., Abbott, C., Lauria, G., Faber, C.G., Soran, H., Efron, N., Boulton, A.J.M., Malik, R.A. (2021) 'Diagnosis of neuropathy and risk factors for corneal nerve loss in type 1 and type 2 diabetes: A corneal confocal microscopy study.' Diabetes Care, 44(1) pp. 150-156.

    Chatwin, K., Abbott, C., Boulton, A., Bowling, F., Reeves, N. (2019) 'The role of foot pressure measurement in the prediction and prevention of diabetic foot ulceration – a comprehensive review.' Diabetes/Metabolism Research and Reviews, 36(4) pp. e3258-e3258.

    Abbott, C.A., Chatwin, K.E., Foden, P., Hasan, A.N., Sange, C., Rajbhandari, S.M., Reddy, P.N., Vileikyte, L., Bowling, F.L., Boulton, A.J.M., Reeves, N.D. (2019) 'Innovative intelligent insole system reduces diabetic foot ulcer recurrence at plantar sites: a prospective, randomised, proof-of-concept study.' The Lancet Digital Health, 1(6) pp. e308-e318.

    Crawford, F., Cezard, G., Chappell, F.M., PODUS Group, (2018) 'The development and validation of a multivariable prognostic model to predict foot ulceration in diabetes using a systematic review and individual patient data meta-analyses.' Diabetic Medicine, 35(11) pp. 1480-1493.

    Fadavi, H., Tavakoli, M., Foden, P., Ferdousi, M., Petropoulos, I., Jeziorska, M., Chaturvedi, N., Boulton, A.J.M., Malik, R.A., Abbott, C.A. (2018) 'Explanations for less small fibre neuropathy in South Asian versus European people with type 2 diabetes mellitus in the UK.' Diabetes - Metabolism: Research and Reviews, 34(7) pp. e3044-e3044.

    Chatwin, K.E., Abbott, C.A., Reddy, P.N., Bowling, F.L., Boulton, A.J.M., Reeves, N.D. (2018) 'A Foreign Body Through the Shoe of a Person With Diabetic Peripheral Neuropathy Alters Contralateral Biomechanics: Captured Through Innovative Plantar Pressure Technology.' International Journal of Lower Extremity Wounds, 17(2) pp. 125-129.

    Yap, M.H., Chatwin, K.E., Ng, C.C., Abbott, C.A., Bowling, F.L., Rajbhandari, S., Boulton, A.J.M., Reeves, N.D. (2017) '"FootSnap": A New Mobile Application for Standardizing Diabetic Foot Images..' Journal of Diabetes Science and Technology, 12(1) pp. 169-173.

    Yap, M.H., Ng, C.C., Chatwin, K., Abbott, C.A., Bowling, F.L., Boulton, A.J.M., Reeves, N.D. (2015) 'Computer vision algorithms in the detection of diabetic foot ulceration: a new paradigm for diabetic foot care?.' Journal of Diabetes Science and Technology, 10(2) pp. 612-613.

    Crawford, F., Anandan, C., Chappell, F.M., Murray, G.D., Price, J.F., Sheikh, A., Simpson, C.R., Maxwell, M., Stansby, G.P., Young, M.J., Abbott, C.A., Boulton, A.J.M., Boyko, E.J., Kastenbauer, T., Leese, G.P., Monami, M., Monteiro-Soares, M., Rith-Najarian, S.J., Veves, A., Coates, N., Jeffcoate, W.J., Leech, N., Fahey, T., Tierney, J. (2013) 'Protocol for a systematic review and individual patient data meta-analysis of prognostic factors of foot ulceration in people with diabetes: the international research collaboration for the prediction of diabetic foot ulcerations (PODUS).' BMC Medical Research Methodology, 13

    Bowling, F.L., Abbott, C.A., Harris, W.E., Atanasov, S., Malik, R.A., Boulton, A.J.M. (2012) 'A pocket-sized disposable device for testing the integrity of sensation in the outpatient setting.' Diabetic Medicine, 29(12) pp. 1550-1552.

    Abbott, C.A., Malik, R.A., Van Ross, E.R.E., Kulkarni, J., Boulton, A.J.M. (2011) 'Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K..' Diabetes Care, 34(10) pp. 2220-2224.

    Tavakoli, M., Quattrini, C., Abbott, C., Kallinikos, P., Marshall, A., Finnigan, J., Morgan, P., Efron, N., Boulton, A.J.M., Malik, R.A. (2010) 'Corneal confocal microscopy: A novel noninvasive test to diagnose and stratify the severity of human diabetic neuropathy.' Diabetes Care, 33(8) pp. 1792-1797.

    Abbott, C.A., Chaturvedi, N., Malik, R.A., Salgami, E., Yates, A.P., Pemberton, P.W., Boulton, A.J.M. (2010) 'Explanations for the lower rates of diabetic neuropathy in Indian Asians versus Europeans.' Diabetes Care, 33(6) pp. 1325-1330.

    VanRoss, E.R., Johnson, S., Abbott, C.A. (2009) 'Effects of Early Mobilization on Unhealed Dysvascular Transtibial Amputation Stumps: A Clinical Trial.' Archives of Physical Medicine and Rehabilitation, 90(4) pp. 610-617.

    Abbott, C.A., Garrow, A.P., Carrington, A.L., Morris, J., Van Ross, E.R., Boulton, A.J. (2005) 'Foot ulcer risk is lower in South-Asian and African-Caribbean compared with European diabetic patients in the U.K.: The North-West diabetes foot care study.' Diabetes Care, 28(8) pp. 1869-1875.

    Malik, R.A., Kallinikos, P., Abbott, C.A., Van Schie, C.H.M., Morgan, P., Efron, N., Boulton, A.J.M. (2003) 'Corneal confocal microscopy: A non-invasive surrogate of nerve fibre damage and repair in diabetic patients.' Diabetologia, 46(5) pp. 683-688.

    Carrington, A.L., Shaw, J.E., Van Schie, C.H.M., Abbott, C.A., Vileikyte, L., Boulton, A.J.M. (2002) 'Can motor nerve conduction velocity predict foot problems in diabetic subjects over a 6-year outcome period?.' Diabetes Care, 25(11) pp. 2010-2015.

    Paisley, A.N., Abbott, C.A., Van Schie, C.H.M., Boulton, A.J.M. (2002) 'A comparison of the Neuropen against standard quantitative sensory-threshold measures for assessing peripheral nerve function.' Diabetic Medicine, 19(5) pp. 400-405.

    Abbott, C.A., Carrington, A.L., Ashe, H., Bath, S., Every, L.C., Griffiths, J., Hann, A.W., Hussein, A., Jackson, N., Johnson, K.E., Ryder, C.H., Torkington, R., Van Ross, E.R.E., Whalley, A.M., Widdows, P., Williamson, S., Boulton, A.J.M. (2002) 'The North-West Diabetes Foot Care Study: Incidence of, and risk factors for, new diabetic foot ulceration in a community-based patient cohort.' Diabetic Medicine, 19(5) pp. 377-384.

    Chaturvedi, N., Abbott, C.A., Whalley, A., Widdows, P., Leggetter, S.Y., Boulton, A.J.M. (2002) 'Risk of diabetes-related amputation in South Asians vs. Europeans in the UK.' Diabetic Medicine, 19(2) pp. 99-104.

    Carrington, A.L., Abbott, C.A., Griffiths, J., Jackson, N., Johnson, S.R., Kulkarni, J., Van Ross, E.R.E., Boulton, A.J.M. (2001) 'Peripheral vascular and nerve function associated with lower limb amputation in people with and without diabetes.' Clinical Science, 101(3) pp. 261-266.

    Carrington, A.L., Abbott, C.A., Griffiths, J., Jackson, N., Johnson, S.R., Kulkarni, J., Van Ross, E.R.E., Boulton, A.J.M. (2001) 'A foot care program for diabetic unilateral lower-limb amputees.' Diabetes Care, 24(2) pp. 216-221.

    Van Schie, C.H.M., Abbott, C.A., Vileikyte, L., Shaw, J.E., Hollis, S., Boulton, A.J.M. (1999) 'A comparative study of the Podotrack, a simple semiquantitative plantar pressure measuring device, and the optical pedobarograph in the assessment of pressures under the diabetic foot.' Diabetic Medicine, 16(2) pp. 154-159.

    Evans, P.M.S., Williams, C., Page, M.D., Alcolado, J.C., Abbott, C.A., van Ross, E.R.E., Kulkarni, J., Shaw, J.E., Carrington, A.L., Boulton, A.J.M. (1999) 'Laterality of lower limb amputation in diabetic patients.' BMJ, 319(7205) pp. 318-318.

    Abbott, C.A., van Ross, E.R., Kulkarni, J., Shaw, J.E., Carrington, A.L., Boulton, A.J. (1999) 'Laterality of lower limb amputation in diabetic patients. Study of 15 636 patients found no influence of laterality on risk of amputation..' BMJ (Clinical research ed.), 319(7205) pp. 318-319.

    Malik, R.A., Williamson, S., Abbott, C., Carrington, A.L., Iqbal, J., Schady, W., Boulton, A.J.M. (1998) 'Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: Randomised double-blind controlled trial.' Lancet, 352(9145) pp. 1978-1981.

    Shaw, J.E., Van Schie, C.H.M., Carrington, A.L., Abbott, C.A., Boulton, A.J.M. (1998) 'An analysis of dynamic forces transmitted through the foot in diabetic neuropathy.' Diabetes Care, 21(11) pp. 1955-1959.

    Abbott, C.A., Vileikyte, L., Williamson, S., Carrington, A.L., Boulton, A.J.M. (1998) 'Multicenter study of the incidence of and predictive risk factors for diabetic neuropathic foot ulceration.' Diabetes Care, 21(7) pp. 1071-1075.

    Jude, E.B., Abbott, C.A., Young, M.J., Anderson, S.G., Douglas, J.T., Boulton, A.J.M. (1998) 'The potential role of cell adhesion molecules in the pathogenesis of diabetic neuropathy.' Diabetologia, 41(3) pp. 330-336.

    Shaw, J.E., Abbott, C.A., Tindle, K., Hollis, S., Boulton, A.J.M. (1997) 'A randomised controlled trial of topical glycopyrrolate, the first specific treatment for diabetic gustatory sweating.' Diabetologia, 40(3) pp. 299-301.

    Abbott, C.A., Mackness, M.I., Kumar, S., Boulton, A.J., Durrington, P.N. (1995) 'Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipids and lipoproteins.' Arteriosclerosis, Thrombosis, and Vascular Biology, 15(11) pp. 1812-1818.

    GARIN, M.C.B., ABBOTT, C., MESSMER, S., MACKNESS, M., DURRINGTON, P., POMETTA, D., JAMES, R.W. (1994) 'QUANTIFICATION OF HUMAN SERUM PARAOXONASE BY ENZYME-LINKED IMMUNOASSAY - POPULATION DIFFERENCES IN PROTEIN CONCENTRATIONS.' BIOCHEMICAL JOURNAL, 304pp. 549-554.

    Mackness, M.I., Arrol, S., Abbott, C.A., Durrington, P.N. (1993) 'Is paraoxonase related to atherosclerosis.' Chemico-Biological Interactions, 87(1-3) pp. 161-171.

    Abbott, C.A., MacKness, M.I., Kumar, S., Olukoga, A.O., Gordon, C., Arrol, S., Bhatnagar, D., Boulton, A.J.M., Durrington, P.N. (1993) 'Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus.' Clinical Science, 85(1) pp. 77-81.

    Mackness, M.I., Arrol, S., Abbott, C., Durrington, P.N. (1993) 'Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase.' Atherosclerosis, 104(1-2) pp. 129-135.

    Mackness, M.I., Abbott, C., Arrol, S., Durrington, P.N. (1993) 'The role of high-density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation.' Biochemical Journal, 294(3) pp. 829-834.

    Morley, B.J., Abbott, C.A., Sharpe, J.A., Lida, J., Chan-Thomas, P.S., Wood, W.G. (1992) 'A single β-globin locus control region element (5′ hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.' Molecular and Cellular Biology, 12(5) pp. 2057-2066.

    Morley, B.J., Abbott, C.A., Wood, W.G. (1991) 'Regulation of human fetal and adult globin genes in mouse erythroleukemia cells.' Blood, 78(5) pp. 1355-1363.

  • Conference papers

    Abbott, C.A., Chatwin, K.E., Hasan, A.N.B., Rajbhandari, S.M., Sange, C., Musa, N., Foden, P., Stocking, K., Vileikyte, L., Bowling, F.L., Boulton, A.J.M., Reeves, N.D. (2018) 'Novel plantar pressure-sensing smart insoles reduce foot ulcer incidence in 'high-risk' diabetic patients: a longitudinal study.' 61. 1/10/2018 - 5/10/2018. Springer Verlag,

    Abbott, C.A., Chatwin, K.E., John, K.M., Pabbineedi, S., Boulton, A.J.M., Bowling, F.L., Reeves, N.D. (2017) 'Site-specific relationship between plantar ulcer sites and elevated peak plantar pressures.' In Diabetes UK Professional Conference 2017. 34. Manchester, 8/3/2017 - 10/3/2017. Wiley for Diabetes UK, pp. 138-138.

    Fadavi, H., Tavakoli, M., Petropolous, I.N., Caturvedi, N., Jeziorska, M., Boulton, A.J.M., Malik, R.A., Abbott, C.A. (2011) 'Potential explanation for lower incidence of foot ulceration in Asian compared to European patients with type 2 diabetes.' In 47th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD). 54. Lisbon, PORTUGAL, 12/9/2011 - 16/9/2011. SPRINGER, pp. S10-S10.

    Abbott, C.A., Naqvi, S., Chaturvedi, N., Malik, R.A., Boulton, A.J.M. (2010) 'Explanations for lower peak plantar foot pressures in Indian Asians versus Europeans with type 2 diabetes.' In 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD). 53. Stockholm, SWEDEN, 20/9/2010 - 24/9/2010. SPRINGER,

Press and media

Media appearances or involvement

BBC1 Inside Out – Interviews and coverage of laboratory activities on research using smart pressure-sensing insoles for diabetic foot ulcer prevention (First aired: 24/10/2016).