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Physiology
The main academic interest is age-related changes in skeletal muscle morphology and function. Thereto we apply single skinned muscles fibres from human muscle biopsies and rodents. The use of single skinned muscle fibres allows one to determine changes in cross-bridge kinetics and fibre function without bias that can be introduced in vivo by e.g. changes in neural drive.
Muscle is highly adaptive and resistance (including overload model in rats) and endurance training are used to assess changes in muscle (fibre) function and morphology. Recently we have also explored how hypoxia does affect the muscle, as not only mountaineers, but also patients with chronic diseases as heart failure and chronic obstructive pulmonary disease and elderly people, may suffer from hypoxia. Of interest is how the muscle adapts to maintain an adequate oxygenation during hypoxia and hypertrophy. The latter is of interest as an increase in fibre size may increase the diffusion distances from the capillaries to the interior of the muscle cell. In smokers this may be aggravated by the presence of carboxyhaemoglobin that not only reduces the oxygen carrying capacity in the blood but also the release of oxygen in the muscle due to the left-shift of the haemoglobin dissociation curve. The impact of smoking and smoking cessation on muscle function is an area of continuing interest. In addition, we have an interest in the impact of space travel on the nueromuscular system.
See academic interests
S. Omairi, A. Matsakas, H. Degens, O. Kretz, KA. Hansson, et al. AV. Solbrå, JC. Bruusgaard, B. Joch, R. Sartori, N. Giallourou, R. Mitchell, H. Collins-Hooper, K. Foster, A. Pasternack, O. Ritvos, M. Sandri, V. Narkar, JR. Swann, T. Huber, K. Patel. (2016). Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres. eLife. 5(AUGUST),
SB. Ballak, H. Degens, A. de Haan, RT. Jaspers (2014). Aging related changes in determinants of muscle force generating capacity: a comparison of muscle aging in men and male rodents. Ageing Res Rev. 14(1), pp.43-55.
Y. Barnouin, JS. McPhee, G. Butler-Browne, A. Bosutti, G. de Vito, et al. DA. Jones, M. Narici, A. Behin, J-Y. Hogrel, H. Degens. Coupling between skeletal muscle fiber size and capillarization is a fundamental characteristic that is maintained during healthy aging. Journal of Cachexia, Sarcopenia and Muscle.
H. Degens (1993). Hypertrophy in the M. Plantaris of the Ageing Rat Functioning and Capillarisation Related to Fibre Types.
H. Degens, A. Swaminathan, J. Tallis (2021). A High Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function. Exercise and Sport Sciences Reviews. 49(4), pp.253-259.
A. Paudyal, H. Degens, GC. Baan, W. Noort, M. Slevin, et al. E. van Wegen, G. Kwakkel, H. Maas. (2021). Changes in muscle-tendon unit length-force characteristics following experimentally induced photothrombotic stroke cannot be explained by changes in muscle belly structure. European Journal of Applied Physiology. 121(9), pp.2509-2519.
B. Ganse, H. Degens (2021). Current Insights in the Age-related Decline in Sports Performance of the Older Athlete. International Journal of Sports Medicine. 42(10), pp.879-888.
LP. Barbosa, S. da Silva Aguiar, PA. Santos, T. Dos Santos Rosa, LA. Maciel, et al. LA. de Deus, RVP. Neves, PL. de Araújo Leite, SD. Gutierrez, CV. Sousa, MT. Korhonen, H. Degens, HG. Simões. (2021). Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes. Experimental Gerontology. 151, pp.111407-111407.
C. Hoog Antink, AK. Braczynski, A. Kleerekoper, H. Degens, B. Ganse (2021). Longitudinal master track and field performance decline rates are lower and performance is better compared to athletes competing only once. The Journals of Gerontology Series A: Biological Sciences. 76(8), pp.1376-1381.
TH. Suominen, M. Alén, T. Törmäkangas, H. Degens, J. Rittweger, et al. A. Heinonen, H. Suominen, MT. Korhonen. (2021). Regular Strength and Sprint Training Counteracts Bone Aging: A 10-Year Follow-Up in Male Masters Athletes. JBMR Plus. 5(7), pp.e10513-e10513.
P. Khanal, L. He, GK. Stebbings, GL. Onambele-Pearson, H. Degens, et al. AG. Williams, M. Thomis, CI. Morse. (2021). Static one-leg standing balance test as a screening tool for low muscle mass in healthy elderly women. Aging Clinical and Experimental Research. 33(7), pp.1831-1839.
A. Kramer, M. Venegas-Carro, J. Zange, W. Sies, NA. Maffiuletti, et al. M. Gruber, H. Degens, M. Moreno-Villanueva, E. Mulder. (2021). Daily 30-min exposure to artificial gravity during 60 days of bed rest does not maintain aerobic exercise capacity but mitigates some deteriorations of muscle function: results from the AGBRESA RCT. European Journal of Applied Physiology. 121(7), pp.2015-2026.
B. Ganse, H. Degens (2021). Declining track and field performance trends in recent years in the Austrian best results 1897-2019. The Journal of Musculoskeletal and Neuronal Interactions. 21(2), pp.196-205.
GL. Onambélé-Pearson, DJ. Tomlinson, CI. Morse, H. Degens (2021). A prolonged hiatus in postmenopausal HRT, does not nullify the therapy’s positive impact on ageing related sarcopenia. PLoS One. 16(5), pp.e0250813-e0250813.
J. Saini, A. Faroni, AJ. Reid, V. Mouly, G. Butler-Browne, et al. AP. Lightfoot, JS. McPhee, H. Degens, N. Al-Shanti. (2021). Cross-talk between motor neurons and myotubes via endogenously secreted neural and muscular growth factors. Physiological Reports. 9(8),
J. Tallis, S. Shelley, H. Degens, C. Hill (2021). Age-related skeletal muscle dysfunction is aggravated by obesity: An investigation of contractile function, implications and treatment. Biomolecules. 11(3), pp.1-31.
P. Hendrickse, H. Degens (2021). Unpreserved muscle function in heart failure with preserved ejection fraction: diffusion limitations defused. Journal of Physiology. 599(5), pp.1361-1362.
GAM. Messa, M. Piasecki, J. Rittweger, JS. McPhee, E. Koltai, et al. Z. Radak, B. Simunic, A. Heinonen, H. Suominen, MT. Korhonen, H. Degens. (2020). Absence of an ageing-related increase in fibre type grouping in athletes and non-athletes. Scandinavian Journal of Medicine and Science in Sports. 30(11), pp.2057-2069.
A. Bosutti, E. Mulder, J. Zange, J. Bühlmeier, B. Ganse, et al. H. Degens. (2020). Effects of 21 days of bed rest and whey protein supplementation on plantar flexor muscle fatigue resistance during repeated shortening contractions. European Journal of Applied Physiology. 120(5), pp.969-983.
J. Dahl, H. Degens, F. Hildebrand, B. Ganse (2020). Do changes in middle-distance running kinematics contribute to the age-related decline in performance?. Journal of musculoskeletal & neuronal interactions. 20(1), pp.94-100.
A. Naderi, F. Shaabani, A. Esmaeili, Z. Salman, E. Borella, et al. H. Degens. (2019). Effects of Low and Moderate Acute Resistance Exercise on Executive Function in Community-Living Older Adults. Sport, Exercise, and Performance Psychology. 8(1), pp.106-122.
I. de Lázaro, A. Yilmazer, Y. Nam, S. Qubisi, FMA. Razak, et al. H. Degens, G. Cossu, K. Kostarelos. (2018). Non-viral, Tumor-free Induction of Transient Cell Reprogramming in Mouse Skeletal Muscle to Enhance Tissue Regeneration. Molecular Therapy. 27(1), pp.59-75.
B. Ganse, H. Degens (2018). Accelerated Decline in Javelin Throwing Performance in Master Athletes 70 Years and Older - Do Changes in Technique Play a Role?. SMIO / Sports Medicine International Open. 2(3), pp.E79-E83.
M. Mickevičius, H. Degens, R. Kesminas, S. Rutkauskas, D. Satkunskienė, et al. K. Vadopalas, K. Pukėnas, J. Jürimäe, A. Skurvydas, S. Kamandulis. (2018). Early anterior knee pain in male adolescent basketball players is related to body height and abnormal knee morphology. Physical Therapy in Sport. 32, pp.273-281.
B. Šimunic, R. Pišot, J. Rittweger, H. Degens (2018). Age-related Slowing of Contractile Properties Differs between Power-, Endurance- and non-athletes; a Tensiomyographic Assessment. Journals of Gerontology, Series A. 73(12), pp.1602-1608.
B. Simunic, H. Degens, K. Koren, J. Zavrsnik, T. Vomut, et al. R. Pisot. (2017). Tensiomyographic assessment of muscle contractile properties in 9- to 14-year old children. International Journal of Sports Medicine. 38(9), pp.659-665.
B. Simunic, H. Degens, J. Zavrsnik, K. Koren, T. Volmut, et al. R. Pisot. (2017). Correction: Tensiomyographic Assessment of Muscle Contractile Properties in 9- to 14-Year Old Children. Int J Sports Med. 38(9), pp.e3-e3.
JS. McPhee, J. Cameron, T. Maden-Wilkinson, M. Piasecki, MH. Yap, et al. DA. Jones, H. Degens. The contributions of fibre atrophy, fibre loss, in situ specific force and voluntary activation to weakness in sarcopenia. Journals of Gerontology, Series A. 73(10), pp.1287-1294.
Y. Barnouin, JS. McPhee, G. Butler-Browne, A. Bosutti, G. De Vito, et al. DA. Jones, M. Narici, A. Behin, J-Y. Hogrel, H. Degens. (2017). Coupling between skeletal muscle fiber size and capillarization is maintained during healthy aging. Journal of Cachexia, Sarcopenia and Muscle. 8(4), pp.647-659.
M. Diaz, H. Degens, L. Vanhees, C. Austin, M. Azzawi (2016). The Effects of Resveratrol on Aging Vessels. Experimental Gerontology. 85, pp.41-47.
M. Mickevičius, S. Rutkauskas, S. Sipavičienė, A. Skurvydas, J. Jürimäe, et al. H. Degens, S. Kamandulis. (2016). Absence of Bilateral Differences in Child Baseball Players with Throwing-related Pain. International Journal of Sports Medicine. 37(12), pp.952-957.
S. van Ginkel, S. Ruoss, P. Valdivieso, H. Degens, S. Waldron, et al. A. de Haan, M. Flück. (2016). ACE inhibition modifies exercise-induced pro-angiogenic and mitochondrial gene transcript expression. Scand J Med Sci Sports. 26(10), pp.1180-1187.
A. Bosutti, M. Salanova, D. Blottner, J. Buehlmeier, E. Mulder, et al. J. Rittweger, MH. Yap, B. Ganse, H. Degens. (2016). Whey protein with potassium bicarbonate supplement attenuates the reduction in muscle oxidative capacity during 19 days bed rest. Journal of Applied Physiology. 121(4), pp.838-848.
S. Omairi, A. Matsakas, H. Degens, O. Kretz, KA. Hansson, et al. AV. Solbrå, JC. Bruusgaard, B. Joch, R. Sartori, N. Giallourou, R. Mitchell, H. Collins-Hooper, K. Foster, A. Pasternack, O. Ritvos, M. Sandri, V. Narkar, JR. Swann, T. Huber, K. Patel. (2016). Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres. eLife. 5(AUGUST),
RA. Grant, N. Cielen, K. Maes, N. Heulens, G. Galli, et al. W. Janssens, G. Gayan-Ramirez, H. Degens. (2016). The effects of smoking on whisker movements: a quantitative measure of exploratory behaviour in rodents. Behavioural Processes. 128, pp.17-23.
Å. Beijer, H. Degens, T. Weber, A. Rosenberger, S. Gehlert, et al. F. Herrera, M. Kohl-Bareis, J. Zange, W. Bloch, J. Rittweger. (2015). Microcirculation of skeletal muscle adapts differently to a resistive exercise intervention with and without superimposed whole-body vibrations. Clin Physiol Funct Imaging. 35(6), pp.425-435.
H. Degens, G. Gayan-Ramirez, HWH. van Hees (2015). Smoking-induced skeletal muscle dysfunction: from evidence to mechanisms. Am J Respir Crit Care Med. 191(6), pp.620-625.
E. Ahmad, MH. Yap, H. Degens, J. McPhee (2014). Enhancement of MRI human thigh muscle segmentation by template-based framework. 2014 IEEE International Conference on Control System, Computing and Engineering (ICCSCE 2014). pp.405-410.
RM. Erskine, AG. Williams, DA. Jones, CE. Stewart, H. Degens (2014). The individual and combined influence of ACE and ACTN3 genotypes on muscle phenotypes before and after strength training. Scand J Med Sci Sports. 24(4), pp.642-648.
E. Ahmad, MH. Yap, H. Degens, JS. McPhee (2014). Atlas-registration based image segmentation of MRI human thigh muscles in 3D space. SPIE Proceedings. 9037,
SB. Ballak, H. Degens, A. de Haan, RT. Jaspers (2014). Aging related changes in determinants of muscle force generating capacity: a comparison of muscle aging in men and male rodents. Ageing Res Rev. 14(1), pp.43-55.
M. Slevin, M. Baldellou, E. Hill, Y. Alexander, G. McDowell, et al. C. Murgatroyd, M. Carroll, H. Degens, J. Krupinski, N. Rovira, M. Chowdhury, F. Serracino-Inglott, L. Badimon. (2014). Novel methods for accurate identification, isolation, and genomic analysis of symptomatic microenvironments in atherosclerotic arteries. Methods Mol Biol. 1135, pp.289-305.
SB. Ballak, H. Degens, T. Busé-Pot, A. de Haan, RT. Jaspers (2014). Plantaris muscle weakness in old mice: relative contributions of changes in specific force, muscle mass, myofiber cross-sectional area, and number. Age (Dordr). 36(6),
H. Degens, JS. McPhee (2014). Muscle Wasting, Dysfunction, and Inflammaging. pp.247-254.
SB. Ballak, H. Degens, T. Busé-Pot, A. de Haan, RT. Jaspers (2014). Plantaris muscle weakness in old mice: relative contributions of changes in specific force, muscle mass, myofiber cross-sectional area, and number. Age (Dordrecht, Netherlands). 36(6),
T. Weber, M. Ducos, E. Mulder, A. Beijer, F. Herrera, et al. J. Zange, H. Degens, W. Bloch, J. Rittweger. (2014). The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading. Clinical Physiology and Functional Imaging. 34(3), pp.218-229.
H. Degens, J. Rittweger, T. Parviainen, KL. Timonen, H. Suominen, et al. A. Heinonen, MT. Korhonen. (2013). Diffusion capacity of the lung in young and old endurance athletes. Int J Sports Med. 34(12), pp.1051-1057.
B. Šimunic, H. Degens, J. Rittweger, M. Narici, V. Pišot, et al. IB. Mekjavic, R. Pišot. (2013). Tensiomyographic measurement of atrophy related processes during bed rest and recovery. European Space Agency, (Special Publication) ESA SP. 706 SP,
A. Ireland, T. Maden-Wilkinson, J. McPhee, K. Cooke, M. Narici, et al. H. Degens, J. Rittweger. (2013). Upper limb muscle-bone asymmetries and bone adaptation in elite youth tennis players. Med Sci Sports Exerc. 45(9), pp.1749-1758.
TM. Maden-Wilkinson, H. Degens, DA. Jones, JS. McPhee (2013). Comparison of MRI and DXA to measure muscle size and age-related atrophy in thigh muscles. J Musculoskelet Neuronal Interact. 13(3), pp.320-328.
TM. Maden-Wilkinson, H. Degens, DA. Jones, JS. McPhee (2013). Comparison of MRI and DXA to measure muscle size and age-related atrophy in thigh muscles. J Musculoskelet Neuronal Interact. 13(3), pp.320-328.
H. Degens, J. Rittweger, T. Parviainen, KL. Timonen, H. Suominen, et al. A. Heinonen, MT. Korhonen. (2013). Diffusion capacity of the lung in young and old endurance athletes. International Journal of Sports Medicine. 34(12), pp.1051-1057.
H. Degens, TM. Maden-Wilkinson, A. Ireland, MT. Korhonen, H. Suominen, et al. A. Heinonen, Z. Radak, JS. McPhee, J. Rittweger. (2013). Relationship between ventilatory function and age in master athletes and a sedentary reference population. Age (Dordr). 35(3), pp.1007-1015.
A. Mithal, J-P. Bonjour, S. Boonen, P. Burckhardt, H. Degens, et al. G. El Hajj Fuleihan, R. Josse, P. Lips, J. Morales Torres, R. Rizzoli, N. Yoshimura, DA. Wahl, C. Cooper, B. Dawson-Hughes, . IOF CSA Nutrition Working Group. (2013). Impact of nutrition on muscle mass, strength, and performance in older adults. Osteoporos Int. 24(5), pp.1555-1566.
A. Mithal, JP. Bonjour, S. Boonen, P. Burckhardt, H. Degens, et al. G. El Hajj Fuleihan, R. Josse, P. Lips, JM. Torres, R. Rizzoli, N. Yoshimura, DA. Wahl, C. Cooper, B. Dawson-Hughes, . IOF CSA Nutrition Working Group. (2013). Erratum to: Impact of nutrition on muscle mass, strength, and performance in older adults. Osteoporos Int. 24(4), pp.1527-1528.
A. Mithal, JP. Bonjour, S. Boonen, P. Burckhardt, H. Degens, et al. G. El Hajj Fuleihan, R. Josse, P. Lips, JM. Torres, R. Rizzoli, N. Yoshimura, DA. Wahl, C. Cooper, B. Dawson-Hughes. (2013). Erratum: Impact of nutrition on muscle mass, strength, and performance in older adults (Osteoporosis International DOI: 10.1007/s00198-012-2236-y)). Osteoporosis International. 24(4), pp.1527-1528.
H. Oushah, M. Saeed, H. Degens, G. Evans, N. Ahmed (2013). The influence of regular moderate exercise on the blood level of advanced glycation end-products (AGEs) in healthy subjects. DIABETIC MEDICINE. 30, pp.49-49.
T. Delhaas, SFT. Van der Meer, G. Schaart, H. Degens, MR. Drost (2013). Steep Increase in Myonuclear Domain Size During Infancy. Anatomical Record. 296(2), pp.192-197.
T. Delhaas, SFT. Van der Meer, G. Schaart, H. Degens, MR. Drost (2013). Steep increase in myonuclear domain size during infancy. Anat Rec (Hoboken). 296(2), pp.192-197.
A. Ireland, J. Rittweger, H. Degens (2013). The Influence of Muscular Action on Bone Strength Via Exercise. Clinical Reviews in Bone and Mineral Metabolism. pp.1-10.
TM. Maden-Wilkinson, JS. McPhee, J. Rittweger, DA. Jones, H. Degens (2013). Thigh muscle volume in relation to age, sex and femur volume. Age. pp.1-11.
L. Hoofd, H. Degens (2013). Statistical treatment of oxygenation-related data in muscle tissue. Advances in Experimental Medicine and Biology. 789, pp.137-142.
T. Weber, M. Ducos, E. Mulder, A. Beijer, F. Herrera, et al. J. Zange, H. Degens, W. Bloch, J. Rittweger. (2013). The relationship between exercise-induced muscle fatigue, arterial blood flow and muscle perfusion after 56 days local muscle unloading. Clinical Physiology and Functional Imaging.
A. Mithal, JP. Bonjour, S. Boonen, P. Burckhardt, H. Degens, et al. G. El Hajj Fuleihan, R. Josse, P. Lips, J. Morales Torres, R. Rizzoli, N. Yoshimura, DA. Wahl, C. Cooper, B. Dawson-Hughes. (2013). Impact of nutrition on muscle mass, strength, and performance in older adults. Osteoporosis International. 24(5), pp.1555-1566.
RM. Erskine, H. Degens (2013). Muscle Growth, Repair and Preservation. pp.247-263.
H. Degens, MT. Korhonen (2012). Factors contributing to the variability in muscle ageing. Maturitas. 73(3), pp.197-201.
RM. Erskine, AG. Williams, DA. Jones, CE. Stewart, H. Degens (2012). Do PTK2 gene polymorphisms contribute to the interindividual variability in muscle strength and the response to resistance training? A preliminary report. JOURNAL OF APPLIED PHYSIOLOGY. 112(8), pp.1329-1334.
A. Ireland, M. Korhonen, A. Heinonen, H. Suominen, C. Baur, et al. S. Stevens, H. Degens, J. Rittweger. (2011). Side-to-side differences in bone strength in master jumpers and sprinters. J Musculoskelet Neuronal Interact. 11(4), pp.298-305.
SFT. Van der Meer, RT. Jaspers, H. Degens (2011). Is the myonuclear domain size fixed?. J Musculoskelet Neuronal Interact. 11(4), pp.286-297.
J. Testerink, RT. Jaspers, J. Rittweger, A. de Haan, H. Degens (2011). Effects of alfacalcidol on circulating cytokines and growth factors in rat skeletal muscle. J Physiol Sci. 61(6), pp.525-535.
JS. McPhee, J. Perez-Schindler, H. Degens, D. Tomlinson, P. Hennis, et al. K. Baar, AG. Williams. (2011). HIF1A P582S gene association with endurance training responses in young women. Eur J Appl Physiol. 111(9), pp.2339-2347.
B. Simunič, H. Degens, J. Rittweger, M. Narici, IB. Mekjavić, et al. R. Pišot. (2011). Noninvasive estimation of myosin heavy chain composition in human skeletal muscle. Med Sci Sports Exerc. 43(9), pp.1619-1625.
JS. McPhee, AG. Williams, J. Perez-Schindler, H. Degens, K. Baar, et al. DA. Jones. (2011). Variability in the magnitude of response of metabolic enzymes reveals patterns of co-ordinated expression following endurance training in women. Exp Physiol. 96(7), pp.699-707.
B. Simunic, H. Degens, J. Rittweger, M. Narici, IB. Mekjavic, et al. R. Pisot. (2011). Noninvasive estimation of myosin heavy chain composition in human skeletal muscle. Medicine & Science in Sports & Exercise.
H. Degens (2011). Physiopathology of muscle in relation to sarcopenia. Journal fur Mineralstoffwechsel. 18(SONDERHEFT 2), pp.6-7.
SF. Gilliver, DA. Jones, J. Rittweger, H. Degens (2011). Variation in the determinants of power of chemically skinned type I rat soleus muscle fibres. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 197(4), pp.311-319.
SFT. van der Meer, RT. Jaspers, DA. Jones, H. Degens (2011). The time course of myonuclear accretion during hypertrophy in young adult and older rat plantaris muscle. Ann Anat. 193(1), pp.56-63.
SF. Gilliver, H. Degens, J. Rittweger, DA. Jones (2011). Effects of submaximal activation on the determinants of power of chemically skinned rat soleus fibres. Exp Physiol. 96(2), pp.171-178.
RM. Erskine, DA. Jones, N. Maffulli, AG. Williams, CE. Stewart, et al. H. Degens. (2011). What causes in vivo muscle specific tension to increase following resistance training?. Exp Physiol. 96(2), pp.145-155.
SFT. van der Meer, RT. Jaspers, DA. Jones, H. Degens (2011). Time-course of changes in the myonuclear domain during denervation in young-adult and old rat gastrocnemius muscle. Muscle Nerve. 43(2), pp.212-222.
J. Testerink, H. Degens, J. Rittweger, A. Shiraishi, RT. Jaspers, et al. A. de Haan. (2011). Effects of alfacalcidol on the contractile properties of the gastrocnemius medialis muscle in adult and old rats. J Physiol Pharmacol. 62(1), pp.111-118.
A. Arampatzis, H. Degens, V. Baltzopoulos, J. Rittweger (2011). Why do older sprinters reach the finish line later?. Exerc Sport Sci Rev. 39(1), pp.18-22.
H. Degens, J. Rittweger (2010). What is new in musculoskeletal interactions? Muscle oxygenation, myonuclear domain, acupuncture, titin and phosphate. J Musculoskelet Neuronal Interact. 10(4), pp.245-248.
SF. Gilliver, DA. Jones, J. Rittweger, H. Degens (2010). Effects of oxidation on the power of chemically skinned rat soleus fibres. J Musculoskelet Neuronal Interact. 10(4), pp.267-273.
RM. Erskine, DA. Jones, AG. Williams, CE. Stewart, H. Degens (2010). Inter-individual variability in the adaptation of human muscle specific tension to progressive resistance training. Eur J Appl Physiol. 110(6), pp.1117-1125.
H. Degens, A. Bosutti, SF. Gilliver, M. Slevin, A. van Heijst, et al. RCI. Wüst. (2010). Changes in contractile properties of skinned single rat soleus and diaphragm fibres after chronic hypoxia. Pflugers Arch. 460(5), pp.863-873.
F. Rauch, H. Sievanen, S. Boonen, M. Cardinale, H. Degens, et al. D. Felsenberg, J. Roth, E. Schoenau, S. Verschueren, J. Rittweger, . International Society of Musculoskeletal and Neuronal Interactions. (2010). Reporting whole-body vibration intervention studies: recommendations of the International Society of Musculoskeletal and Neuronal Interactions. J Musculoskelet Neuronal Interact. 10(3), pp.193-198.
JS. McPhee, AG. Williams, H. Degens, DA. Jones (2010). Inter-individual variability in adaptation of the leg muscles following a standardised endurance training programme in young women. Eur J Appl Physiol. 109(6), pp.1111-1118.
V. Goosey-Tolfrey, E. Foden, C. Perret, H. Degens (2010). Effects of inspiratory muscle training on respiratory function and repetitive sprint performance in wheelchair basketball players. BRITISH JOURNAL OF SPORTS MEDICINE. 44(9), pp.665-668.
J. Rittweger, AD. Moss, W. Colier, C. Stewart, H. Degens (2010). Muscle tissue oxygenation and VEGF in VO-matched vibration and squatting exercise. Clin Physiol Funct Imaging. 30(4), pp.269-278.
RCI. Wüst, K. Winwood, DC. Wilks, CI. Morse, H. Degens, et al. J. Rittweger. (2010). Effects of smoking on tibial and radial bone mass and strength may diminish with age. J Clin Endocrinol Metab. 95(6), pp.2763-2771.
RM. Erskine, DA. Jones, AG. Williams, CE. Stewart, H. Degens (2010). Resistance training increases in vivo quadriceps femoris muscle specific tension in young men. Acta Physiol (Oxf). 199(1), pp.83-89.
H. Degens (2010). The role of systemic inflammation in age-related muscle weakness and wasting. Scand J Med Sci Sports. 20(1), pp.28-38.
RA. Needham, CI. Morse, H. Degens (2009). The acute effect of different warm-up protocols on anaerobic performance in elite youth soccer players. J Strength Cond Res. 23(9), pp.2614-2620.
SF. Gilliver, H. Degens, J. Rittweger, AJ. Sargeant, DA. Jones (2009). Variation in the determinants of power of chemically skinned human muscle fibres. Exp Physiol. 94(10), pp.1070-1078.
RM. Erskine, DA. Jones, CN. Maganaris, H. Degens (2009). In vivo specific tension of the human quadriceps femoris muscle. Eur J Appl Physiol. 106(6), pp.827-838.
RCI. Wüst, RT. Jaspers, AF. van Heijst, MTE. Hopman, LJC. Hoofd, et al. WJ. van der Laarse, H. Degens. (2009). Region-specific adaptations in determinants of rat skeletal muscle oxygenation to chronic hypoxia. Am J Physiol Heart Circ Physiol. 297(1), pp.H364-H374.
L. Hoofd, H. Degens (2009). The influence of flow redistribution on working rat muscle oxygenation. Adv Exp Med Biol. 645, pp.55-60.
RCI. Wüst, SL. Gibbings, H. Degens (2009). Fiber capillary supply related to fiber size and oxidative capacity in human and rat skeletal muscle. Adv Exp Med Biol. 645, pp.75-80.
H. Degens, RM. Erskine, CI. Morse (2009). Disproportionate changes in skeletal muscle strength and size with resistance training and ageing. J Musculoskelet Neuronal Interact. 9(3), pp.123-129.
RCI. Wüst, RT. Jaspers, WJ. van der Laarse, H. Degens (2008). Skeletal muscle capillarization and oxidative metabolism in healthy smokers. Appl Physiol Nutr Metab. 33(6), pp.1240-1245.
H. Degens (2008). Elevated plasma ACE activity: no guarantee for enhanced left ventricular hypertrophy during training. Acta Physiol (Oxf). 194(2),
RCI. Wüst, CI. Morse, A. de Haan, J. Rittweger, DA. Jones, et al. H. Degens. (2008). Skeletal muscle properties and fatigue resistance in relation to smoking history. Eur J Appl Physiol. 104(1), pp.103-110.
RCI. Wüst, CI. Morse, A. de Haan, DA. Jones, H. Degens (2008). Sex differences in contractile properties and fatigue resistance of human skeletal muscle. Exp Physiol. 93(7), pp.843-850.
RCI. Wüst, H. Degens, DA. Jones (2008). Muscle function in smokers: clearing up the smoke. Chest. 134(1), pp.219-220.
H. Degens, SN. Koşar, MTE. Hopman, A. de Haan (2008). The time course of denervation-induced changes is similar in soleus muscles of adult and old rats. Appl Physiol Nutr Metab. 33(2), pp.299-308.
CI. Morse, LJ. Pritchard, RCI. Wüst, DA. Jones, H. Degens (2008). Carbon monoxide inhalation reduces skeletal muscle fatigue resistance. Acta Physiol (Oxf). 192(3), pp.397-401.
CI. Morse, H. Degens, OR. Seynnes, CN. Maganaris, DA. Jones (2008). The acute effect of stretching on the passive stiffness of the human gastrocnemius muscle tendon unit. J Physiol. 586(1), pp.97-106.
TM. Altenburg, H. Degens, W. van Mechelen, AJ. Sargeant, A. de Haan (2007). Recruitment of single muscle fibers during submaximal cycling exercise. J Appl Physiol (1985). 103(5), pp.1752-1756.
CI. Morse, RCI. Wüst, DA. Jones, A. de Haan, H. Degens (2007). Muscle fatigue resistance during stimulated contractions is reduced in young male smokers. Acta Physiol (Oxf). 191(2), pp.123-129.
H. Degens, AK. Swisher, YF. Heijdra, PM. Siu, PNR. Dekhuijzen, et al. SE. Alway. (2007). Apoptosis and Id2 expression in diaphragm and soleus muscle from the emphysematous hamster. Am J Physiol Regul Integr Comp Physiol. 293(1), pp.R135-R144.
CI. Morse, H. Degens, DA. Jones (2007). The validity of estimating quadriceps volume from single MRI cross-sections in young men. Eur J Appl Physiol. 100(3), pp.267-274.
S. Fredericks, H. Degens, G. McKoy, K. Bainbridge, PO. Collinson, et al. G. Coulton, H. Elmahdi, DW. Holt. (2007). Effect of denervation on the content of cardiac troponin-T and cardiac troponin-I in rat skeletal muscle. Clin Biochem. 40(5-6), pp.423-426.
H. Degens (2007). Age-related skeletal muscle dysfunction: causes and mechanisms. J Musculoskelet Neuronal Interact. 7(3), pp.246-252.
RCI. Wüst, H. Degens (2007). Factors contributing to muscle wasting and dysfunction in COPD patients. Int J Chron Obstruct Pulmon Dis. 2(3), pp.289-300.
H. Degens, L. Larsson (2007). Application of skinned single muscle fibres to determine myofilament function in ageing and disease. J Musculoskelet Neuronal Interact. 7(1), pp.56-61.
GLN. Onambélé, H. Degens (2006). Improvements in muscle-tendon properties are beneficial to balance in multiple sclerosis. Mult Scler. 12(5), pp.666-669.
H. Degens, D. Deveci, A. Botto-van Bemden, LJC. Hoofd, S. Egginton (2006). Maintenance of heterogeneity of capillary spacing is essential for adequate oxygenation in the soleus muscle of the growing rat. Microcirculation. 13(6), pp.467-476.
KFJ. de Brouwer, H. Degens, WM. Aartsen, M. Lindhout, NJJE. Bitsch, et al. AJ. Gilde, PHM. Willemsen, BJA. Janssen, GJ. van der Vusse, M. van Bilsen. (2006). Specific and sustained down-regulation of genes involved in fatty acid metabolism is not a hallmark of progression to cardiac failure in mice. J Mol Cell Cardiol. 40(6), pp.838-845.
H. Degens, JM. Sanchez Horneros, MTE. Hopman (2006). Acute hypoxia limits endurance but does not affect muscle contractile properties. Muscle Nerve. 33(4), pp.532-537.
M. Faes, N. van Elk, JA. de Lint, H. Degens, JGM. Kooloos, et al. MTE. Hopman. (2006). A dynamic extensor brace reduces electromyographic activity of wrist extensor muscles in patients with lateral epicondylalgia. J Orthop Sports Phys Ther. 36(3), pp.170-178.
H. Degens, SE. Alway (2006). Control of muscle size during disuse, disease, and aging. Int J Sports Med. 27(2), pp.94-99.
H. Degens, KFJ. de Brouwer, AJ. Gilde, M. Lindhout, PHM. Willemsen, et al. BJ. Janssen, GJ. van der Vusse, M. van Bilsen. (2006). Cardiac fatty acid metabolism is preserved in the compensated hypertrophic rat heart. Basic Res Cardiol. 101(1), pp.17-26.
CAC. Ottenheijm, LMA. Heunks, GC. Sieck, W-Z. Zhan, SM. Jansen, et al. H. Degens, T. de Boo, PNR. Dekhuijzen. (2005). Diaphragm dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 172(2), pp.200-205.
H. Degens, JM. Sanchez Horneros, YF. Heijdra, PNR. Dekhuijzen, MTE. Hopman (2005). Skeletal muscle contractility is preserved in COPD patients with normal fat-free mass. Acta Physiol Scand. 184(3), pp.235-242.
G. Mckoy, Y. Hou, SY. Yang, D. Vega Avelaira, H. Degens, et al. G. Goldspink, GR. Coulton. (2005). Expression of Ankrd2 in fast and slow muscles and its response to stretch are consistent with a role in slow muscle function. J Appl Physiol (1985). 98(6), pp.2337-2343.
N. van Elk, M. Faes, H. Degens, JGM. Kooloos, JA. de Lint, et al. MTE. Hopman. (2004). The application of an external wrist extension force reduces electromyographic activity of wrist extensor muscles during gripping. J Orthop Sports Phys Ther. 34(5), pp.228-234.
SE. Alway, H. Degens, G. Krishnamurthy, A. Chaudhrai (2003). Denervation stimulates apoptosis but not Id2 expression in hindlimb muscles of aged rats. J Gerontol A Biol Sci Med Sci. 58(8), pp.687-697.
H. Degens, JA. Moore, SE. Alway (2003). Vascular endothelial growth factor, capillarization, and function of the rat plantaris muscle at the onset of hypertrophy. Jpn J Physiol. 53(3), pp.181-191.
H. Degens, SE. Alway (2003). Skeletal muscle function and hypertrophy are diminished in old age. Muscle Nerve. 27(3), pp.339-347.
Y. Barnouin, JS. McPhee, G. Butler-Browne, A. Bosutti, G. de Vito, et al. DA. Jones, M. Narici, A. Behin, J-Y. Hogrel, H. Degens. Coupling between skeletal muscle fiber size and capillarization is a fundamental characteristic that is maintained during healthy aging. Journal of Cachexia, Sarcopenia and Muscle.
H. Degens, AJ. Gilde, M. Lindhout, PHM. Willemsen, GJ. Van Der Vusse, et al. M. Van Bilsen. (2003). Functional and metabolic adaptation of the heart to prolonged thyroid hormone treatment. Am J Physiol Heart Circ Physiol. 284(1), pp.H108-H115.
SE. Alway, H. Degens, G. Krishnamurthy, CA. Smith (2002). Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats. Am J Physiol Cell Physiol. 283(1), pp.C66-C76.
SE. Alway, H. Degens, DA. Lowe, G. Krishnamurthy (2002). Increased myogenic repressor Id mRNA and protein levels in hindlimb muscles of aged rats. Am J Physiol Regul Integr Comp Physiol. 282(2), pp.R411-R422.
H. Degens, RK. Anderson, SE. Alway (2002). Capillarization in skeletal muscle of rats with cardiac hypertrophy. Med Sci Sports Exerc. 34(2), pp.258-266.
DA. Lowe, H. Degens, KD. Chen, SE. Alway (2000). Glyceraldehyde-3-phosphate dehydrogenase varies with age in glycolytic muscles of rats. J Gerontol A Biol Sci Med Sci. 55(3), pp.B160-B164.
F. Yu, H. Degens, L. Larsson (1999). The influence of thyroid hormone on myosin isoform composition and shortening velocity of single skeletal muscle fibres with special reference to ageing and gender. Acta Physiol Scand. 167(4), pp.313-316.
H. DEGENS, M. SOOP, P. HÖÖK, O. LJUNGQVIST, L. LARSSON (1999). Post-operative effects on insulin resistance and specific tension of single human skeletal muscle fibres. Clinical Science. 97(4), pp.449-455.
Abstract.
H. Degens, M. Soop, P. Höök, O. Ljungqvist, L. Larsson (1999). Post-operative effects on insulin resistance and specific tension of single human skeletal muscle fibres. Clin Sci (Lond). 97(4), pp.449-455.
F. Yu, H. Degens, X. Li, L. Larsson (1998). Gender- and age-related differences in the regulatory influence of thyroid hormone on the contractility and myosin composition of single rat soleus muscle fibres. Pflugers Arch. 437(1), pp.21-30.
S. Salmons, AT. Tang, JC. Jarvis, H. Degens, M. Hastings, et al. TL. Hooper. (1998). Morphological and functional evidence, and clinical importance, of vascular anastomoses in the latissimus dorsi muscle of the sheep. J Anat. 193 ( Pt 1)(Pt 1), pp.93-104.
H. Degens, S. Salmons, JC. Jarvis (1998). Intramuscular pressure, force and blood flow in rabbit tibialis anterior muscles during single and repetitive contractions. Eur J Appl Physiol Occup Physiol. 78(1), pp.13-19.
H. Degens, F. Yu, X. Li, L. Larsson (1998). Effects of age and gender on shortening velocity and myosin isoforms in single rat muscle fibres. Acta Physiol Scand. 163(1), pp.33-40.
F. Yu, H. Degens, X. Li, L. Larsson (1998). Gender- and age-related differences in the regulatory influence of thyroid hormone on contractility and expression of myosin isoforms in single rat soleus muscle fibres. FASEB Journal. 12(4),
H. Degens (1998). Age-related changes in the microcirculation of skeletal muscle. Adv Exp Med Biol. 454, pp.343-348.
CA. van Doorn, H. Degens, MS. Bhabra, CB. Till, TE. Shaw, et al. JC. Jarvis, S. Salmons, TL. Hooper. (1997). Intramural blood flow of skeletal muscle ventricles functioning as aortic counterpulsators. Ann Thorac Surg. 64(1), pp.86-93.
L. Larsson, X. Li, F. Yu, H. Degens (1997). Age-related changes in contractile properties and expression of myosin isoforms in single skeletal muscle cells. Muscle and Nerve. 20(SUPPL. 5),
L. Larsson, X. Li, F. Yu, H. Degens (1997). Age-related changes in contractile properties and expression of myosin isoforms in single skeletal muscle cells. Muscle Nerve Suppl. 5, pp.S74-S78.
H. Degens, AJ. Craven, JC. Jarvis, S. Salmons (1996). The use of coloured dye-extraction microspheres to measure blood flow in rabbit skeletal muscle: a validation study with special emphasis on repeated measurements. Exp Physiol. 81(2), pp.239-249.
H. Degens, NE. Meessen, P. Wirtz, RA. Binkhorst (1995). The development of compensatory hypertrophy in the plantaris muscle of the rat. Ann Anat. 177(3), pp.285-289.
H. Degens, L. Hoofd, RA. Binkhorst (1995). Specific force of the rat plantaris muscle changes with age, but not with overload. Mech Ageing Dev. 78(3), pp.215-219.
WN. Colier, IB. Meeuwsen, H. Degens, B. Oeseburg (1995). Determination of oxygen consumption in muscle during exercise using near infrared spectroscopy. Acta Anaesthesiol Scand Suppl. 107, pp.151-155.
H. Degens, JH. Veerkamp (1994). Changes in oxidative capacity and fatigue resistance in skeletal muscle. Int J Biochem. 26(7), pp.871-878.
H. Degens, BE. Ringnalda, LJ. Hoofd (1994). Capillarisation, fibre types and myoglobin content of the dog gracilis muscle. Adv Exp Med Biol. 361, pp.533-539.
H. Degens, Z. Turek, LJ. Hoofd, RA. Binkhorst (1994). Capillary proliferation related to fibre types in hypertrophied aging rat M. plantaris. Adv Exp Med Biol. 345, pp.669-676.
H. Degens, Z. Turek, L. Hoofd, MA. van't Hof, RA. Binkhorst (1993). Capillarisation and fibre types in hypertrophied m. plantaris in rats of various ages. Respir Physiol. 94(2), pp.217-226.
H. Degens, JH. Veerkamp, HT. van Moerkerk, Z. Turek, LJ. Hoofd, et al. RA. Binkhorst. (1993). Metabolic capacity, fibre type area and capillarization of rat plantaris muscle. Effects of age, overload and training and relationship with fatigue resistance. Int J Biochem. 25(8), pp.1141-1148.
H. Degens, Z. Turek, RA. Binkhorst (1993). Compensatory hypertrophy and training effects on the functioning of aging rat m. plantaris. Mech Ageing Dev. 66(3), pp.299-311.
H. Degens, Z. Turek, LJ. Hoofd, MA. Van't Hof, RA. Binkhorst (1992). The relationship between capillarisation and fibre types during compensatory hypertrophy of the plantaris muscle in the rat. J Anat. 180 ( Pt 3)(Pt 3), pp.455-463.
R. Erskine, H. Degens (2019). Nutrition and Enhanced Sports Performance. D. Bagchi, S. Nair, CK. Sen. In: Nutrition and Enhanced Sports Performance; 2nd edition. London: Elsevier, pp.291-308.
H. Degens (2019). Human Ageing. In: Muscle and Exercise Physiology. Elsevier, pp.423-432.
RM. Erskine, H. Degens (2019). Muscle Growth, Repair, and Preservation. In: Nutrition and Enhanced Sports Performance. Elsevier, pp.291-308.
H. Degens (2018). Human Ageing. In: Muscle and Exercise Physiology. pp.423-432.
H. Degens, RK. Anderson, SE. Alway (2003). Capillarization and vascular endothelial growth factor expression in hypertrophying anterior latissimus dorsi muscle of the Japanese quail. pp.577-585.
H. Degens, S. Salmons, JC. Jarvis (1995). Mean blood flow and intramuscular pressure during cyclic activity in the rabbit tibilais anterior muscle. In: Proceedings EC Concerted Action Heart. Skeletal Muscle Assist Working Group, BIOMED-I. European Union, pp.9-13.
H. Degens, Z. Turek, RA. Binkhorst (1993). Fatigue in hypertrophied m.plantaris: age, capillarization and fibre type effects. AJ. Sageant, D. Kernell. In: Neuromuscular Fatigue. North Holland, Amsterdam: Academy Series, Royal Netherlands Academy of Arts and Sciences,- Elsevier, pp.69-70.
G. Montgomery, M. Darabseh, P. Ocana, K. Ishihara, A. Aburub, et al. F. Zambolin, R. Mills, M. Scorcelletti, B. Ganse, H. Degens, L. Bagley. Proportionate age-related declines in muscle strength, respiratory function and performance in Master Track Cyclists. In: https://www.physoc.org/abstracts/proportionate-age-related-declines-in-muscle-strength-respiratory-function-and-performance-in-master-track-cyclists/. Online, 19/4/2021.
M. Darabseh, P. Ocana, K. Ishihara, A. Aburub, F. Zambolin, et al. G. Montgomery, M. Scorcelletti, B. Ganse, H. Degens, L. Bagley. Proportionate age-related declines in muscle strength, respiratory function and performance in Master Track Cyclists. In: Proc Physiol Soc 47. Virtual, 19/4/2021.
S. Satta, M. McElroy, A. Langford-Smith, G. Ferris, J. Teasdale, et al. Y. Kim, G. Niccoli, A. Tanjeko, J. Serré, G. Hazell, G. Sala-Newby, P. Wang, J. Johnson, M. Humphries, G. Gayan-Ramirez, P. Libby, F. Crea, H. Degens, F. Gijsen, T. Johnson, A. Keshmiri, Y. Alexander, A. Newby, S. White. (2019). 143 A pivotal role for NRF2 in endothelial detachment–implications for endothelial erosion of stenotic plaques. In: Acute Coronary Syndromes. Manchester, ENGLAND, 3/6/2019. pp.A118-A118.
E. Ahmad, JS. McPhee, H. Degens, MH. Yap (2018). Automatic Segmentation of MRI Human Thigh Muscles. In: Proceedings of the 2018 8th International Conference on Biomedical Engineering and Technology. pp.31-38.
MH. Yap, AN. Baharum, G. Ferris, H. Degens, EF. Ahmad Shaubari (2018). Capillary detection in transverse muscle sections. In: Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging. Houston, TX, 10/2/2018.
JA. Wullems, CI. Morse, H. Degens, SMP. Verschueren, G. Onambele-Pearson (2015). What is a physiologically relevant epoch length in sedentarism?. Kaunas, Lithuania, 12/11/2015.
JA. Wullems, D. Ryan, CI. Morse, H. Degens, SMP. Verschueren, et al. GL. Onsmbele-Pearson. (2015). Algorithm development for objectively monitoring physical activity and sedentary behaviour. Regensburg, Germany, 12/6/2015.
M. Diaz, H. Degens, C. Austin, M. Azzawi (2015). 207 The Vascular Effects of Resveratrol on Aged Mouse Femoral Arteries. In: Heart. Manchester, ENGLAND, 8/6/2015. pp.A114.1-A114.
J. Wullems, D. Ryan, CI. Morse, H. Degens, SMP. Verschueren, et al. GL. Onambele-Pearson. (2015). A novel Triaxial accelerometer data algorithm in the quantification of physical activity and sedentary behaviour in young and older adults. British Society for Research on Ageing. Genome campus: Hinxton, Cambridge, 18/5/2015.
L. Hoofd, H. Degens (2013). Statistical Treatment of Oxygenation-Related Data in Muscle Tissue. In: Advances in Experimental Medicine and Biology. pp.137-142.
H. Degens, CI. Morse, MTE. Hopman (2009). Heterogeneity of capillary spacing in the hypertrophied plantaris muscle from young-adult and old rats. In: Adv Exp Med Biol. United States, pp.61-66.
JS. McPhee, H. Degens, DA. Jones, K. Baar, AG. Williams (2009). Individual variability in skeletal muscle metabolic response to endurance training in humans. In: Proceedings of the Physiological Society. London, UK, 2009. pp.31P-32P.
Engagement and Knowledge Exchange
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2015-present Visting Professor Lithuanian Sport University
2018-present Visting Professor University of Medicine and Pharmacy of Targu Mures, Rumania
2017 Doctor Honouris Causa Lithuanian Sport UNiversity, Kaunas.