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https://webcdn.mmu.ac.uk/profiles/img/profile-images/Caroline-Abbott-crop-145x145-60488128207ec.jpg
PhD
PhD supervision to completion and in progress
I am a Research Fellow in Department of Life Sciences, Faculty of Science and Engineering at Manchester Metropolitan University.
I have been active in clinical research of diabetic lower limb disease for over 25 years, in particular: epidemiology and aetiology of diabetic foot ulcers, diabetic neuropathy, peripheral vascular disease and lower limb amputation. I have a special interest in the ethnic variations associated with risk of diabetic lower limb disease. My research in clinical movement disorders includes: diabetic plantar forces during gait, comparative plantar pressure measuring devices, and use of smart technologies for diabetic foot ulcer prevention. My publications have had over 7,000 citations and a H-index of 27 (Google scholar).
I am currently leading a pilot clinical trial of a new medical device for remote diabetic foot ulcer prevention (joint Chief Investigator, and Principal Investigator).
FM. Chappell, F. Crawford, M. Horne, GP. Leese, A. Martin, et al. D. Weller, AJM. Boulton, C. Abbott, M. Monteiro-Soares, A. Veves, RD. Riley. (2021). Development and validation of a clinical prediction rule for development of diabetic foot ulceration: an analysis of data from five cohort studies. BMJ Open Diabetes Research and Care. 9,
FM. Chappell, F. Crawford, M. Horne, GP. Leese, A. Martin, et al. D. Weller, AJM. Boulton, C. Abbott, M. Monteiro-Soares, A. Veves, RD. Riley. (2021). Development and validation of a clinical prediction rule for development of diabetic foot ulceration: an analysis of data from five cohort studies. BMJ Open Diabetes Research and Care. 9,
F. Crawford, G. Cezard, FM. Chappell, . PODUS Group (2018). The development and validation of a multivariable prognostic model to predict foot ulceration in diabetes using a systematic review and individual patient data meta-analyses. Diabetic Medicine. 35(11), pp.1480-1493.
FL. Bowling, CA. Abbott, WE. Harris, S. Atanasov, RA. Malik, et al. AJM. Boulton. (2012). A pocket-sized disposable device for testing the integrity of sensation in the outpatient setting. Diabet Med. 29(12), pp.1550-1552.
ER. Vanross, S. Johnson, CA. Abbott (2009). Effects of early mobilization on unhealed dysvascular transtibial amputation stumps: a clinical trial. Arch Phys Med Rehabil. 90(4), pp.610-617.
CA. Abbott, AP. Garrow, AL. Carrington, J. Morris, ER. Van Ross, et al. AJ. Boulton, . North-West diabetes foot care study. (2005). Foot ulcer risk is lower in South-Asian and african-Caribbean compared with European diabetic patients in the U.K.: the North-West diabetes foot care study. Diabetes Care. 28(8), pp.1869-1875.
RA. Malik, P. Kallinikos, CA. Abbott, CHM. van Schie, P. Morgan, et al. N. Efron, AJM. Boulton. (2003). Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Diabetologia. 46(5), pp.683-688.
AL. Carrington, JE. Shaw, CHM. Van Schie, CA. Abbott, L. Vileikyte, et al. AJM. Boulton. (2002). Can motor nerve conduction velocity predict foot problems in diabetic subjects over a 6-year outcome period?. Diabetes Care. 25(11), pp.2010-2015.
CA. Abbott, AL. Carrington, H. Ashe, S. Bath, LC. Every, et al. J. Griffiths, AW. Hann, A. Hussein, N. Jackson, KE. Johnson, CH. Ryder, R. Torkington, ERE. Van Ross, AM. Whalley, P. Widdows, S. Williamson, AJM. Boulton, . North-West Diabetes Foot Care Study. (2002). The North-West Diabetes Foot Care Study: incidence of, and risk factors for, new diabetic foot ulceration in a community-based patient cohort. Diabet Med. 19(5), pp.377-384.
AN. Paisley, CA. Abbott, CHM. van Schie, AJM. Boulton (2002). A comparison of the Neuropen against standard quantitative sensory-threshold measures for assessing peripheral nerve function. Diabet Med. 19(5), pp.400-405.
N. Chaturvedi, CA. Abbott, A. Whalley, P. Widdows, SY. Leggetter, et al. AJM. Boulton. (2002). Risk of diabetes-related amputation in South Asians vs. Europeans in the UK. Diabet Med. 19(2), pp.99-104.
AL. Carrington, CA. Abbott, J. Griffiths, N. Jackson, SR. Johnson, et al. J. Kulkarni, ER. Van Ross, AJ. Boulton. (2001). Peripheral vascular and nerve function associated with lower limb amputation in people with and without diabetes. Clin Sci (Lond). 101(3), pp.261-266.
AL. Carrington, CA. Abbott, J. Griffiths, N. Jackson, SR. Johnson, et al. J. Kulkarni, ER. Van Ross, AJ. Boulton. (2001). A foot care program for diabetic unilateral lower-limb amputees. Diabetes Care. 24(2), pp.216-221.
CA. Abbott, ER. van Ross, J. Kulkarni, JE. Shaw, AL. Carrington, et al. AJ. Boulton. (1999). Laterality of lower limb amputation in diabetic patients. Study of 15 636 patients found no influence of laterality on risk of amputation. BMJ. 319(7205), pp.318-319.
PMS. Evans, C. Williams, MD. Page, JC. Alcolado, CA. Abbott, et al. ERE. van Ross, J. Kulkarni, JE. Shaw, AL. Carrington, AJM. Boulton. (1999). Laterality of lower limb amputation in diabetic patients. BMJ. 319(7205), pp.318-318.
CH. van Schie, CA. Abbott, L. Vileikyte, JE. Shaw, S. Hollis, et al. AJ. Boulton. (1999). A comparative study of the Podotrack, a simple semiquantitative plantar pressure measuring device, and the optical pedobarograph in the assessment of pressures under the diabetic foot. Diabet Med. 16(2), pp.154-159.
RA. Malik, S. Williamson, C. Abbott, AL. Carrington, J. Iqbal, et al. W. Schady, AJ. Boulton. (1998). Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: randomised double-blind controlled trial. Lancet. 352(9145), pp.1978-1981.
JE. Shaw, CH. van Schie, AL. Carrington, CA. Abbott, AJ. Boulton (1998). An analysis of dynamic forces transmitted through the foot in diabetic neuropathy. Diabetes Care. 21(11), pp.1955-1959.
CA. Abbott, L. Vileikyte, S. Williamson, AL. Carrington, AJ. Boulton (1998). Multicenter study of the incidence of and predictive risk factors for diabetic neuropathic foot ulceration. Diabetes Care. 21(7), pp.1071-1075.
EB. Jude, CA. Abbott, MJ. Young, SG. Anderson, JT. Douglas, et al. AJ. Boulton. (1998). The potential role of cell adhesion molecules in the pathogenesis of diabetic neuropathy. Diabetologia. 41(3), pp.330-336.
JE. Shaw, CA. Abbott, K. Tindle, S. Hollis, AJ. Boulton (1997). A randomised controlled trial of topical glycopyrrolate, the first specific treatment for diabetic gustatory sweating. Diabetologia. 40(3), pp.299-301.
CA. Abbott, MI. Mackness, S. Kumar, AJ. Boulton, PN. Durrington (1995). Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipids and lipoproteins. Arterioscler Thromb Vasc Biol. 15(11), pp.1812-1818.
MC. Blatter Garin, C. Abbott, S. Messmer, M. Mackness, P. Durrington, et al. D. Pometta, RW. James. (1994). Quantification of human serum paraoxonase by enzyme-linked immunoassay: population differences in protein concentrations. Biochem J. 304 ( Pt 2)(Pt 2), pp.549-554.
MI. Mackness, S. Arrol, C. Abbott, PN. Durrington (1993). Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis. 104(1-2), pp.129-135.
MI. Mackness, C. Abbott, S. Arrol, PN. Durrington (1993). The role of high-density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation. Biochem J. 294 ( Pt 3)(Pt 3), pp.829-834.
CA. Abbott, MI. Mackness, S. Kumar, AO. Olukoga, C. Gordon, et al. S. Arrol, D. Bhatnagar, AJ. Boulton, PN. Durrington. (1993). Relationship between serum butyrylcholinesterase activity, hypertriglyceridaemia and insulin sensitivity in diabetes mellitus. Clin Sci (Lond). 85(1), pp.77-81.
MI. Mackness, S. Arrol, CA. Abbott, PN. Durrington (1993). Is paraoxonase related to atherosclerosis. Chem Biol Interact. 87(1-3), pp.161-171.
BJ. Morley, CA. Abbott, JA. Sharpe, J. Lida, PS. Chan-Thomas, et al. WG. Wood. (1992). A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice. Mol Cell Biol. 12(5), pp.2057-2066.
BJ. Morley, CA. Abbott, WG. Wood (1991). Regulation of human fetal and adult globin genes in mouse erythroleukemia cells. Blood. 78(5), pp.1355-1363.
ND. Reeves, B. Cassidy, CA. Abbott, MH. Yap (2021). Novel technologies for detection and prevention of diabetic foot ulcers. In: The Science, Etiology and Mechanobiology of Diabetes and its Complications. Elsevier, pp.107-122.
CA. Abbott (2019). Epidemiology of amputation and the influence of ethnicity. In: The Foot in Diabetes, 5th Edition. John Wiley and Sons Ltd,
H. Fadavi, M. Tavakoli, IN. Petropolous, N. Caturvedi, M. Jeziorska, et al. AJM. Boulton, RA. Malik, CA. Abbott. (2011). Potential explanation for lower incidence of foot ulceration in Asian compared to European patients with type 2 diabetes. In: DIABETOLOGIA. Lisbon, PORTUGAL, 12/9/2011. pp.S10-S10.
CA. Abbott, S. Naqvi, N. Chaturvedi, RA. Malik, AJM. Boulton (2010). Explanations for lower peak plantar foot pressures in Indian Asians versus Europeans with type 2 diabetes. In: DIABETOLOGIA. Stockholm, SWEDEN, 20/9/2010.
I am an expert reviewer for journals Diabetes Care, Diabetologia, PLOS One, Medicina
January 2021 £~45,000 “A Pilot Study to Investigate the Use of Remote Thermovisual Monitoring in Patients with a Previous Diabetic Foot Ulcer, during the COVID-19 pandemic”
BBC1 Inside Out – Interviews and coverage of laboratory activities on research using smart pressure-sensing insoles for diabetic foot ulcer prevention (First aired: 24/10/2016).
Highly Commended’ in the Quality in Care Diabetes awards category: Seven Thousand Feet. ‘Diabetes Collaboration Initiative of the year – Adults’. 2019.
Best Public Engagement Contribution Award at The Greater Manchester Clinical Research Network part of the National Institute for Health Research: ‘Seven Thousand Feet’ (Art-Science event on diabetes), October 2019.
Outstanding Contribution to Patient and Public Involvement and Engagement 2019: 'Seven Thousand Feet'. University of Manchester PPIE event: July 2019.
Prize Lecture - The Paul Wilson Brand Repetitive Stress Award (2018), Diabetic Foot Study Group meeting, Berlin, Germany.
Young Investigator Clinical Science Award for 2007, NEURODIAB European Association for the Study of Diabetes (EASD) meeting, Utrecht, Netherlands.
Editorial Board member for Medicina (international, open access journal) - since March 2021.