Chemistry
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The MChem (Hons) Chemistry is an integrate…
Dr Ryan Mewis MRSC PGCAP FHEA
Senior Lecturer in Inorganic Chemistry
My profile
Biography
Ryan Mewis graduated from the University of Hull with a MChem (Hons) in 2005 and subsequently obtained a PhD in inorganic chemistry from the same institution by working on the “Synthesis of Tetraazamacrocycles: Biomedical Applications” under the supervision of Drs Archibald and Boyle. In 2009 he joined the group of Professor Simon Duckett at the University of York as a Postdoctoral Fellow to work on a project related to the hyperpolarisation technique SABRE (Signal Amplification By Reversible Exchange) entitled the “Chemical Aspects of Hyperpolarisation”. This project, which was part of a joint collaboration with Professor Gary Green (University of York), was focused on developing what is primarily a spectroscopic technique, to one that can be used in clinical diagnosis.
In February 2015, Dr Mewis joined the staff at Manchester Metropolitan University as a Lecturer in Inorganic Chemistry. He was promoted to Senior Lecturer in 2016.
Dr Mewis is a member of the Royal Society of Chemistry (RSC).
Prizes and awards
In 2019 I was awarded best Undergraduate Supervisor of the year and best Postgraduate Supervisor at the Manchester Metropolitan University Teaching Awards
Membership of professional associations
Member of the Royal Society of Chemistry
Interests and expertise
Research Interests
- Development of catalysts for use with the hyperpolarisation technique SABRE (Signal Amplification By Reversible Exchange)
- Utilizing SABRE towards different applications
- Application of NMR to routine drug testing
- Macrocyclic complexes directed towards biomedical applications
Prospective students looking for either MSc or PhD positions are strongly encouraged to contact Dr Ryan Mewis prior to applying.
Expert reviewer for external funding bodies
Member of the Subject Expert Grant Assessment Panel (SEGAP) for the RSC
I also review papers for Analytical Methods, Journal of Physical Chemistry, Analytical Chemistry, Reaction Kinetics, Mechanisms and Catalysis, Chemistry - A European Journal, Journal of the American Chemical Society, Journal of Chemical Education, Mangetic Resonance in Chemistry and Forensic Chemistry
See here for more details https://publons.com/author/981223/ryan-e-mewis#profile
Consultancy and advisory roles
I act as a consultant for Oxford Instruments
Expert reviewer for external funding bodies
Member of the Subject Expert Grant Assessment Panel for the RSC
Projects
Current Projects
Current projects are focused on the following:
- Detection of drugs using multi-modal approaches e.g. GC-MS, IR and NMR
- Hyperpolarisation of metal complexes by SABRE.
Academic collaborations
I work very closely with Dr Oliver Sutcliffe (MMU) on Novel Psychoactive Substance based projects. I have also published extensively with Prof. E. Kate Kemsley (Quadram Institute) on how to use automated NMR for the detection and qualitative analysis of drugs within a seized sample.
Teaching
Why do I teach?
I teach because I enjoy the challenge of empowering the next generation of chemists with the knowledge that they need to move on with their chosen careers. I am a firm believer in research-led teaching and utilize examples from current and past research exploits where possible.
I recognize that obtaining a degree is a long and sometimes arduous journey - I know that I worked very hard for my degree. One of the greatest joys of my job is seeing students obtaining the best degree possible, especially when they have suffered setbacks along the way. I am always happy to help students who are struggling, and even more so when the student in question has invested substantial effort in trying to elucidate the answer for themselves.
How I’ll teach you
I teach using lectures, which incorporate formative assessments so that students can appraise their own learning, alongside tutorials that are student led. I also facilitate laboratory classes at a number of levels of our courses. I also develop new experiments for laboratory classes to enhance student learning with associated virtual learning environment support so that students can appraise their own learning and develop confidence prior to entering the laboratory.
I am also involved in the development of smart worksheets for assessment purposes so that students can obtain instantaneous feedback on their work.
Why study…
Chemistry is an exciting and diverse subject that, as the middle science, also encompasses aspects of physics and biology. Chemists are at the forefront of key scientific discoveries that improve our daily lives such as helping to combat disease or producing stronger and more durable materials.
Obtaining a degree in chemistry doesn’t stop there - it will empower you with valuable transferable skills such as problem solving, team-working and independency (particularly of importance for project modules). A chemistry degree doesn’t mean that you have to go on to do a chemistry orientated job, instead it gives you wide-ranging opportunities when you have graduated. However, if a chemistry orientated job is what you want to go on to do, then you will be equipped with relevant and up-to-date analytical skills, reinforced with the relevant chemical knowledge, that will be what future employers are looking for.
Undergraduate courses
Teaching specialisms cover NMR and inorganic reaction mechanisms
I currently teach on:
6F7Z2103 Further Topics in Analysis, Synthesis & Catalytic Chemistry
6F7Z2104 Frontiers in Pharmaceutical Chemistry
6F7Z2002 Frontiers in Chemical and Environmental Science
6F7Z2101 Advanced Project and Personal Development (Unit leader)
6F6Z2101C Project and Personal Development for Chemists
6F6Z2101P Project and Personal Development for Pharmaceutical Chemists
6F5Z2017 Spectroscopy and instrumental Analysis (Csup)
6F5Z2110 Structure and Spectroscopy
6F5Z2102 Solid state, d-block and f-block Chemistry
6F5Z2101 Laboratory Techniques 2
6F4Z2111 Laboratory Techniques 1A (Unit Leader)
6F4Z2112 Laboratory Techniques 1B (Unit Leader)
6F3Z3006 Introductory Chemical Reactions and Mechanisms
6F3Z3005 Principles of Chemistry
I am also the year leader for year 4 of the MChem course
Science and Engineering degrees with a foundation year (Biology and Chemistry route)
Watch our video of Biological Sciences student, Megan has she gives us a glimpse into what life was like on her year-long placement at Chester Zoo.
The foundation year provides a route onto a biology…
Supervision
Current students
Emily Griffiths - PhD (principal Supervisor)
Alex Wilcock - PhD (principal Supervisor)
Conner Maccullum – MSc (second supervisor)
David Dixon – PhD (second supervisor)
Previous Students
Faye Own – MSc (graduated 2017 (second supervisor))
Thomas Tennant – MSc (graduated 2018 (principal supervisor))
Christopher Turnbull – MSc (graduated 2019 (second supervisor))
Armita Hayathakbsh – MSc (graduated 2019 (principal supervisor))
Thomas Robertson – PhD (graduated 2020 (principal supervisor))
Matthew Hulme – PhD (graduated 2020 (second supervisor))
Nicolas Gilbert – PhD (graduated 2021 (second supervisor))
Jack Marron – PhD (second supervisor)
Soliman Alkirit – PhD (second supervisor)
J. Hena Hussain – MSc (graduated 2020 (second supervisor))
Filip Zukowicz – MSc (second supervisor)
Prospective students looking for either MSc or PhD positions are strongly encouraged to contact Dr Ryan Mewis prior to applying.
Research outputs
- Development of catalysts for use with the hyperpolarisation technique SABRE (Signal Amplification By Reversible Exchange)
- Utilising SABRE towards different applications.
- I am also interested in the use of macrocyclic complexes towards biomedical applications
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Chapters in books
Equbal, A., Mewis, R. (2023) 'Hyperpolarisation Techniques.' Nuclear Magnetic Resonance Volume 49. Royal Society of Chemistry,
Mewis, R.E., Wilcock, A. (2022) 'Hyperpolarisation Techniques.' Nuclear Magnetic Resonance: Volume 48. Royal Society of Chemistry,
Mewis, R. (2021) 'Hyperpolarisation techniques.' In Hodgkinson, P. (ed.) Nuclear Magnetic Resonance: Volume 47. Royal Society of Chemistry, pp. 151-182.
Sutcliffe, O.B., Mewis, R.E. (2020) 'Nuclear Magnetic Resonance Spectroscopy.' Clarke’s Analysis of Drugs and Poisons. Pharmaceutical Press,
Robertson, T.B.R., Mewis, R.E. (2018) 'Perspective on the Hyperpolarisation Technique Signal Amplification by Reversible Exchange (SABRE) in NMR Spectroscopy and MR Imaging.' Elsevier, pp. 145-212.
Duckett, S.B., Mewis, R.E. (2014) 'Erratum to: Improving NMR and MRI Sensitivity with Parahydrogen.' Hyperpolarization Methods in NMR Spectroscopy. Springer Berlin Heidelberg, pp. E1-E1.
Duckett, S.B., Mewis, R.E. (2012) 'Improving NMR and MRI Sensitivity with Parahydrogen.' Hyperpolarization Methods in NMR Spectroscopy. Springer Berlin Heidelberg, pp. 75-103.
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Reports
Caprio, V., Sutcliffe, O.B., Mewis, R. (2018) Analysis of the reduction product of 3-nitrobenzaldehyde using Pulsar. Oxford Instruments.
Ashworth, D., Clayton, L., Mewis, R. (2015) Using Pulsar to measure spin-lattice relaxation data to determine the longevity of polarised spin-states produced by a parahydrogen based hyperpolarisation technique. Oxford Instruments.
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Journal articles
Dixon, D.I., Millea, M.F., Wilcock, A.T.M., Costello, A., Ellison, J.R., Lord, S., O'Brian, K.A., Mewis, R.E., Sutcliffe, O.B. (2023) 'Synthesis, characterisation and quantification of the new psychoactive substance 1-(1,3-benzodioxol-5-yl)-2-(propylamino)butan-1-one (bk-PBDB, putylone).' Forensic Chemistry, 35pp. 100523-100523.
Sutcliffe, O.B., Mewis, R.E., Kemsley, E.K., Williamson, D.C. (2022) '3,4-Methylenedioxymethamphetamine quantification via benchtop 1H qNMR spectroscopy: method validation and its application to ecstasy tablets collected at music festivals.' Journal of Pharmaceutical and Biomedical Analysis, 221pp. 115042-115042.
Dixon, D.I., Antonides, L.H., Costello, A., Crane, B., Embleton, A., Fletcher, M.L., Gilbert, N., Hulme, M.C., James, M.J., Lever, M.A., Maccallum, C.J., Millea, M.F., Pimlott, J.L., Robertson, T.B.R., Rudge, N.E., Schofield, C.J., Zukowicz, F., Kemsley, E.K., Sutcliffe, O., Mewis, R.E. (2022) 'Comparative study of the analysis of seized samples by GC-MS, 1H NMR and FT-IR spectroscopy within a Night-Time Economy (NTE) setting.' Journal of Phamaceutical and Biomedical Analysis, 219pp. 114950-114950.
Cochrane, G., Field, J.K., Hulme, M.C., Gilbert, N., Mewis, R.E., Euerby, M.R., Sutcliffe, O.B. (2022) 'Guilty by Dissociation: Part B: Evaluation of Supercritical Fluid Chromatography (SFC-UV) for the analysis of regioisomeric diphenidine-derived Novel Psychoactive Substances (NPS).' Journal of Pharmaceutical and Biomedical Analysis, 216pp. 114797-114797.
Field, J.K., Hinz, C., Titman, C.M., Hulme, M.C., Cowan, R.M., Ainsworth-McMillan, J.B., Gilbert, N., Lee, R.J., Marron, J., Costello, A., Mewis, R.E., Euerby, M.R., Sutcliffe, O.B. (2022) 'Guilty by Dissociation: Part A: Development of a rapid Ultra-High Performance Liquid Chromatography (UHPLC)-MS/MS methodology for the analysis of regioisomeric diphenidine-derived Novel Psychoactive Substances (NPS).' Journal of Pharmaceutical and Biomedical Analysis, 216pp. 114798-114798.
Robertson, T.B.R., Clarke, L.J., Mewis, R.E. (2022) 'Rapid SABRE Catalyst Scavenging Using Functionalized Silicas.' Molecules, 27(2) pp. 332-332.
Mewis, R.E. (2021) 'Signal amplification by reversible exchange (SABRE).' Magnetic Resonance in Chemistry, 59(12) pp. 1175-1176.
Gilbert, N., Costello, A., Ellison, J.R., Khan, U., Knight, M., Linnell, M.J., Ralphs, R., Mewis, R.E., Sutcliffe, O.B. (2021) 'Synthesis, characterisation, detection and quantification of a novel hexyl-substituted synthetic cannabinoid receptor agonist: (S)-N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-hexyl-1H-indazole-3-carboxamide (ADB-HINACA).' Forensic Chemistry, 26pp. 100354-100354.
Robertson, T.B.R., Gilbert, N., Sutcliffe, O.B., Mewis, R.E. (2021) 'Hyperpolarisation of Mirfentanil by SABRE in the Presence of Heroin.' ChemPhysChem, 22(11) pp. 1059-1064.
Hulme, M.C., Hayatbakhsh, A., Brignall, R.M., Gilbert, N., Costello, A., Schofield, C.J., Williamson, D.C., Kemsley, E.K., Sutcliffe, O.B., Mewis, R.E. (2021) 'Detection, discrimination and quantification of amphetamine, cathinone and nor-ephedrine regioisomers using benchtop 1H and 19F NMR spectroscopy.' Magnetic Resonance in Chemistry (MRC), 61(2) pp. 73-82.
Gilbert, N., Mewis, R.E., Sutcliffe, O.B. (2021) 'Fast & Fluorinated – Development and validation of a rapid benchtop NMR approach and other routine screening methods for the detection and quantification of synthesised fluorofentanyl derivatives.' Forensic Chemistry, 23pp. 100321-100321.
Gilbert, N., Mewis, R.E., Sutcliffe, O.B. (2020) 'Classification of fentanyl analogues through principal component analysis (PCA) and hierarchical clustering of GC–MS data.' Forensic Chemistry, 21pp. 100287-100287.
Hussain, J.H., Gilbert, N., Costello, A., Schofield, C.J., Kemsley, E.K., Sutcliffe, O.B., Mewis, R.E. (2020) 'Quantification of MDMA in seized tablets using benchtop 1H NMR spectroscopy in the absence of internal standards.' Forensic Chemistry, 20pp. 100263-100263.
Morgan, B.G., Warren, P., Mewis, R.E., Rivett, D.W. (2020) 'Bacterial dominance is due to effective utilisation of secondary metabolites produced by competitors..' Scientific reports, 10(1) pp. 2316-2316.
Gilbert, N., Antonides, L.H., Schofield, C.J., Costello, A., Kilkelly, B., Cain, A.R., Dalziel, P.R.V., Horner, K., Mewis, R.E., Sutcliffe, O.B. (2020) 'Hitting the Jackpot – development of gas chromatography–mass spectrometry (GC–MS) and other rapid screening methods for the analysis of 18 fentanyl-derived synthetic opioids.' Drug Testing and Analysis, 12(6) pp. 798-811.
Tennant, T., Hulme, M.C., Robertson, T.B.R., Sutcliffe, O.B., Mewis, R.E. (2020) 'Benchtop NMR analysis of piperazine-based drugs hyperpolarised by SABRE.' Magnetic resonance in chemistry : MRC, 58(12) pp. 1151-1159.
Robertson, T.B.R., Antonides, L.H., Gilbert, N., Benjamin, S.L., Langley, S.K., Munro, L.J., Sutcliffe, O.B., Mewis, R.E. (2019) 'Hyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE).' ChemistryOpen, 8pp. 1-9.
Elbardisy, H.M., Foster, C.W., Marron, J., Mewis, R.E., Sutcliffe, O.B., Belal, T.S., Talaat, W., Daabees, H.G., Banks, C.E. (2019) 'Quick Test for Determination of N-Bombs (Phenethylamine Derivatives, NBOMe) Using High-Performance Liquid Chromatography: A Comparison between Photodiode Array and Amperometric Detection.' ACS Omega, 4pp. 14439-14450.
Mewis, R.E., Archibald, S.J. (2019) 'Side-bridged cyclam transition metal complexes bearing a phenolic ether or a phenolate pendent arm.' Polyhedron, 171pp. 578-589.
Dobzhenetskiy, A., Gater, C.A., Wilcock, A.T.M., Langley, S., Brignall, R.M., Williamson, D.C., Mewis, R. (2019) 'Utilisation of the static Evans method to measure magnetic susceptibilities of transition metal acetylacetonate complexes as part of an undergraduate inorganic laboratory class.' Chemistry: Bulgarian Journal of Science Education, 28(3) pp. 339-350.
Antonides, L.H., Brignall, R.M., Costello, A., Ellison, J., Firth, S.E., Gilbert, N., Groom, B.J., Hudson, S.J., Hulme, M.C., Marron, J., Pullen, Z.A., Robertson, T.B.R., Schofield, C.J., Williamson, D.C., Kemsley, E.K., Sutcliffe, O.B., Mewis, R.E. (2019) 'Rapid Identification of Novel Psychoactive and Other Controlled Substances Using Low-Field 1H NMR Spectroscopy.' ACS Omega, 4(4) pp. 7103-7112.
Richards, J.E., Hooper, A.J.J., Bayfield, O.W., Cockett, M.C.R., Dear, G.J., Holmes, A.J., John, R.O., Mewis, R., Pridmore, N., Roberts, A.D., Whitwood, A.C., Duckett, S.B. (2018) 'Using hyperpolarised NMR and DFT to rationalise the unexpected hydrogenation of quinazoline to 3,4-dihydroquinazoline.' Chemical Communications,
Caprio, V., McLachlan, A.S., Sutcliffe, O.B., Williamson, D.C., Mewis, R.E. (2018) 'Structural elucidation of unknowns: a spectroscopic investigation with an emphasis on 1D and 2D nuclear magnetic resonance spectroscopy.' Chemistry: Bulgarian Journal of Science Education, 27(2) pp. 223-234.
Lowdon, J.W., Alkirkit, S.M.O., Mewis, R.E., Fulton, D., Banks, C.E., Sutcliffe, O.B., Peeters, M. (2018) 'Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers..' Analyst, 143pp. 2002-2007.
Norcott, P., Burns, M.J., Rayner, P.J., Mewis, R.E., Duckett, S.B. (2017) 'Using 2H Labelling to Improve the NMR Detectability of Pyridine and its Derivatives by SABRE.' Magnetic Resonance in Chemistry, 56(7) pp. 663-671.
Olaru, A.M., Robertson, T.B.R., Lewis, J.S., Antony, A., Iali, W., Mewis, R.E., Duckett, S.B. (2017) 'Extending the Scope of 19F Hyperpolarization through Signal Amplification by Reversible Exchange in MRI and NMR Spectroscopy.' ChemistryOpen, 7(1) pp. 97-105.
Aranburu Leiva, A.I., Kaur, M., Benjamin, S.L., Jones, A.M., Langley, S.K., Mewis, R.E. (2017) '1,8-bis(2-hydroxy-3,5-di-tert-butylbenzyl)-4,11-dibenzyl-1,4,8,11-tetraazacyclotetradecane.' Molbank, 4
Rayner, P.J., Burns, M.J., Olaru, A.M., Norcott, P., Fekete, M., Green, G.G.R., Highton, L.A.R., Mewis, R.E., Duckett, S.B. (2017) 'Delivering strong (1)H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange..' Proceedings of the National Academy of Sciences of the United States of America, 114(16)
Fernandez Diaz-Rullo, F., Zamberlan, F., Mewis, R.E., Fekete, M., Broche, L., Cheyne, L.A., Dall'Angelo, S., Duckett, S.B., Dawson, D., Zanda, M. (2017) 'Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy..' Bioorganic and Medicinal Chemistry, 25(10) pp. 2730-2742.
Mewis, R.E., Aranburu Leiva, A.I., Benjamin, S.L., Langley, S.K. (2016) 'Crystal structure of 2,4-di-tert-butyl-6-(hydroxymethyl)phenol.' Acta Crystallographica Section E: Crystallographic Communications, 72pp. 1614-1617.
Maples, R.D., Cain, A.N., Burke, B.P., Silversides, J.D., Mewis, R.E., D'huys, T., Schols, D., Linder, D.P., Archibald, S.J., Hubin, T.J. (2016) 'Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.' Chemistry: A European Journal, 22(36) pp. 12916-12930.
Rovedo, P., Knecht, S., Bäumlisberger, T., Cremer, A.L., Duckett, S.B., Mewis, R.E., Green, G.G.R., Burns, M., Rayner, P.J., Leibfritz, D., Korvink, J.G., Hennig, J., Pütz, G., Von Elverfeldt, D., Hövener, J.B. (2016) 'Molecular MRI in the Earth's Magnetic Field Using Continuous Hyperpolarization of a Biomolecule in Water.' Journal of Physical Chemistry B, 120(25) pp. 5670-5677.
Mewis, R.E. (2015) 'Developments and advances concerning the hyperpolarisation technique SABRE.' Magnetic Resonance in Chemistry, 53
Appleby, K.M., Mewis, R.E., Olaru, A.M., Green, G.G.R., Fairlamb, I.J.S., Duckett, S.B. (2015) 'Investigating pyridazine and phthalazine exchange in a series of iridium complexes in order to define their role in the catalytic transfer of magnetisation from para-hydrogen..' Chem Sci, 6(7) pp. 3981-3993.
Mewis, R.E., Fekete, M., Green, G.G.R., Whitwood, A.C., Duckett, S.B. (2015) 'Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application..' Chem Commun (Camb), 51(48) pp. 9857-9859.
Duckett, S.B., Mewis, R.E. (2015) 'ChemInform Abstract: Improving NMR and MRI Sensitivity with Para Hydrogen.' ChemInform, 46(26)
Ruddlesden, A.J., Mewis, R.E., Green, G.G.R., Whitwood, A.C., Duckett, S.B. (2015) 'Catalytic Transfer of Magnetism Using a Neutral Iridium Phenoxide Complex.' Organometallics, 34(12) pp. 2997-3006.
Burns, M.J., Rayner, P.J., Green, G.G.R., Highton, L.A.R., Mewis, R.E., Duckett, S.B. (2015) 'Improving the Hyperpolarization of P-31 Nuclei by Synthetic Design.' JOURNAL OF PHYSICAL CHEMISTRY B, 119
Mewis, R.E., Green, R.A., Cockett, M.C.R., Cowley, M.J., Duckett, S.B., Green, G.G.R., John, R.O., Rayner, P.J., Williamson, D.C. (2015) 'Strategies for the hyperpolarization of acetonitrile and related Ligands by SABRE.' Journal of Physical Chemistry B, 119(4) pp. 1416-1424.
Lloyd, L.S., Asghar, A., Burns, M.J., Charlton, A., Coombes, S., Cowley, M.J., Dear, G.J., Duckett, S.B., Genov, G.R., Green, G.G.R., Highton, L.A.R., Hooper, A.J.J., Khan, M., Khazal, I.G., Lewis, R.J., Mewis, R.E., Roberts, A.D., Ruddlesden, A.J. (2014) 'Hyperpolarisation through reversible interactions with parahydrogen.' Catalysis Science and Technology, 4(10) pp. 3544-3554.
Fekete, M., Bayfield, O.W., Duckett, S.B., Hart, S., Mewis, R.E., Pridmore, N., Rayner, P.J., Whitwood, A. (2014) 'Erratum: Iiridium(III) hydrido N-heterocyclic carbene-phosphine complexes as catalysts in magnetization transfer reactions (Inorganic Chemistry (2013) 52:23 (13453-13461) DOI:10.1021/ic401783c).' Inorganic Chemistry, 53(5)
Fekete, M., Bayfield, O.W., Duckett, S.B., Hart, S., Mewis, R.E., Pridmore, N., Rayner, P.J., Whitwood, A. (2014) 'Iridium(III) Hydrido N-Heterocyclic Carbene-Phosphine Complexes as Catalysts in Magnetization Transfer Reactions (vol 52, pg 13453, 2013).' INORGANIC CHEMISTRY, 53(5) pp. 2749-2749.
Hövener, J.B., Schwaderlapp, N., Borowiak, R., Lickert, T., Duckett, S.B., Mewis, R.E., Adams, R.W., Burns, M.J., Highton, L.A.R., Green, G.G.R., Olaru, A., Hennig, J., Von Elverfeldt, D. (2014) 'Toward biocompatible nuclear hyperpolarization using signal amplification by reversible exchange: Quantitative in situ spectroscopy and high-field imaging.' Analytical Chemistry, 86(3) pp. 1767-1774.
Mewis, R.E., Atkinson, K.D., Cowley, M.J., Duckett, S.B., Green, G.G.R., Green, R.A., Highton, L.A.R., Kilgour, D., Lloyd, L.S., Lohman, J.A.B., Williamson, D.C. (2014) 'Probing signal amplification by reversible exchange using an NMR flow system.' Magnetic Resonance in Chemistry, 52(7) pp. 358-369.
Hövener, J.B., Schwaderlapp, N., Lickert, T., Duckett, S.B., Mewis, R.E., Highton, L.A.R., Kenny, S.M., Green, G.G.R., Leibfritz, D., Korvink, J.G., Hennig, J., von Elverfeldt, D. (2013) 'A hyperpolarized equilibrium for magnetic resonance..' Nat Commun, 4
Fekete, M., Bayfield, O., Duckett, S.B., Hart, S., Mewis, R.E., Pridmore, N., Rayner, P.J., Whitwood, A. (2013) 'Iridium(III) hydrido N-heterocyclic carbene-phosphine complexes as catalysts in magnetization transfer reactions.' Inorganic Chemistry, 52(23) pp. 13453-13461.
Duckett, S.B., Mewis, R.E. (2013) 'Improving NMR and MRI sensitivity with parahydrogen.' Topics in Current Chemistry, 338pp. 75-104.
Zeng, H., Xu, J., Gillen, J., McMahon, M.T., Artemov, D., Tyburn, J.M., Lohman, J.A.B., Mewis, R.E., Atkinson, K.D., Green, G.G.R., Duckett, S.B., Van Zijl, P.C.M. (2013) 'Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid.' Journal of Magnetic Resonance, 237pp. 73-78.
Smith, R., Huskens, D., Daelemans, D., Mewis, R.E., Garcia, C.D., Cain, A.N., Freeman, T.R.N.C., Pannecouque, C., Clercq, E.D., Schols, D., Hubin, T.J., Archibald, S.J. (2012) 'CXCR4 chemokine receptor antagonists: Nickel(ii) complexes of configurationally restricted macrocycles.' Dalton Transactions, 41(37) pp. 11369-11377.
Green, R.A., Adams, R.W., Duckett, S.B., Mewis, R.E., Williamson, D.C., Green, G.G.R. (2012) 'The theory and practice of hyperpolarization in magnetic resonance using parahydrogen.' Progress in Nuclear Magnetic Resonance Spectroscopy, 67pp. 1-48.
Duckett, S.B., Mewis, R.E. (2012) 'Application of para hydrogen induced polarization techniques in NMR spectroscopy and imaging.' Accounts of Chemical Research, 45(8) pp. 1247-1257.
Lloyd, L.S., Adams, R.W., Bernstein, M., Coombes, S., Duckett, S.B., Green, G.G.R., Lewis, R.J., Mewis, R.E., Sleigh, C.J. (2012) 'Utilization of SABRE-derived hyperpolarization to detect low-concentration analytes via 1D and 2D NMR methods.' Journal of the American Chemical Society, 134(31) pp. 12904-12907.
Cowley, M.J., Adams, R.W., Atkinson, K.D., Cockett, M.C.R., Duckett, S.B., Green, G.G.R., Lohman, J.A.B., Kerssebaum, R., Kilgour, D., Mewis, R.E. (2011) 'Iridium N-heterocyclic carbene complexes as efficient catalysts for magnetization transfer from para-hydrogen..' J Am Chem Soc, 133(16) pp. 6134-6137.
Sparke, A.E., Fisher, C.M., Mewis, R.E., Archibald, S.J. (2010) 'Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole.' Tetrahedron Letters, 51(36) pp. 4723-4726.
Mewis, R.E., Archibald, S.J. (2010) 'Biomedical applications of macrocyclic ligand complexes.' Coordination Chemistry Reviews, 254(15-16) pp. 1686-1712.
Mewis, R.E., Savoie, H., Archibald, S.J., Boyle, R.W. (2009) 'Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand.' Photodiagnosis and Photodynamic Therapy, 6(3-4) pp. 200-206.
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Patents
Sutcliffe, O.B., Mewis, R., Williamson, D. (2018) A method for screening psychoactive substances.
Career history
Sept 2016 onwards
Senior lecturer in Inorganic Chemistry at Manchester Metropolitan University.
Feb 2015 - Aug 2016
Lecturer in Inorganic Chemistry at Manchester Metropolitan University.
Jan 2013-Jan 2015
Research Fellow based in CHyM (Centre for Hyperpolarisation in MRI) at the University of York
Jan 2012 - Jan 2013
Research and teaching fellow at the University of York
Mar 2009 - Jan 2012
Post-doctoral researcher at the University of York